2-({[(Benzyloxy)carbonyl]amino}methyl)butanedioic acid | 1233513-29-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-({[(Benzyloxy)carbonyl]amino}methyl)butanedioic acid
• 英文别名: 2-(phenylmethoxycarbonylaminomethyl)butanedioic acid
• CAS: 1233513-29-5
• 化学式: C₁₃H₁₅NO₆
• 分子量: 281.26
• InChiKey: HUYOAMJOIPBORO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples
  申请人：Chang Chiu Chin

  公开号：US20090263879A1

  公开（公告）日：2009-10-22

  This invention pertains to a method for detecting a compound in the presence of other compounds that are substantially similar in structure and metabolically related to the analyte. The invention is particularly suited for the detection of S-adenosylmethionine in the presence of S-adenosylhomocysteine, other nucleosides and derivatives in a biological sample. The methods of this invention involve an antibody produced specifically against S-adenosylmethionine; particularly, analogs modified strategically at the sulfonium position. An assay protocol comprises chemically modified analyte analog linked to an enzymatic reporter and the aforementioned antibody was used to demonstrate the assay specificity and sensitivity. Additional assay method with immobilized immunogen, the specific antibody, and an enzyme labeled secondary antibody was also described for illustration. The invention also features hapten design and novel compounds used as haptens to prepare immunogen and for the specific antibody production.

  本发明涉及一种在存在结构上与待分析物相似且代谢相关的其他化合物的情况下检测化合物的方法。本发明特别适用于在生物样品中检测S-腺苷甲硫氨酸，尤其是在存在S-腺苷同型半胱氨酸、其他核苷和衍生物的情况下。本发明的方法涉及针对S-腺苷甲硫氨酸特异性产生的抗体，特别是在硫杂环丙烷位点上进行战略性修饰的类似物。检测方案包括化学修饰的待分析物类似物与酶标记的报告物链接，并使用上述抗体来证明检测的特异性和灵敏度。此外，还描述了一种具有固定的免疫原、特异性抗体和酶标记的二级抗体的附加检测方法，以进行说明。本发明还具有半抗原设计和用作半抗原制备免疫原和特异性抗体生产的新化合物。
• US8344115B2
  申请人：——

  公开号：US8344115B2

  公开（公告）日：2013-01-01
• [EN] IMMUNOASSAY FOR SPECIFIC DETERMINATION OF S-ADENOSYMETHIONINE AND ANALOGS THEREOF IN BIOLOGICAL SAMPLES<br/>[FR] DOSAGE IMMUNOLOGIQUE POUR LA DÉTERMINATION SPÉCIFIQUE DE LA S-ADÉNOSYLMÉTHIONINE ET DE SES ANALOGUES DANS DES ÉCHANTILLONS BIOLOGIQUES
  申请人：MONABIO INC

  公开号：WO2009131643A1

  公开（公告）日：2009-10-29

  This invention pertains to a method for detecting a compound in the presence of other compounds that are substantially similar in structure and metabolically related to the analyte. The invention is particularly suited for the detection of S-adenosylmethionine in the presence of S-adenosylhomocysteine, other nucleosides and derivatives in a biological sample. The methods of this invention involve an antibody produced specifically against S-adenosylmethionine; particularly, analogs modified strategically at the sulfonium position. An assay protocol comprises chemically modified analyte analog linked to an enzymatic reporter and the aforementioned antibody was used to demonstrate the assay specificity and sensitivity. Additional assay method with immobilized immunogen, the specific antibody, and an enzyme labeled secondary antibody was also described for illustration. The invention also features hapten design and novel compounds used as haptens to prepare immunogen and for the specific antibody production.