2-[5-(acetylamino)-2-methyl-4-({4-methyl-2-[4-(trifluoromethyl)phenyl](1,3-thiazol-5-yl)}methylthio)phenoxy]acetic acid | 600134-45-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[5-(acetylamino)-2-methyl-4-({4-methyl-2-[4-(trifluoromethyl)phenyl](1,3-thiazol-5-yl)}methylthio)phenoxy]acetic acid
• 英文别名: 2-[5-Acetamido-2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
• CAS: 600134-45-0
• 化学式: C₂₃H₂₁F₃N₂O₄S₂
• 分子量: 510.558
• InChiKey: SPIHNOZNJYIWEG-UHFFFAOYSA-N

物化性质

• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Compounds that modulate PPAR activity and methods of preparation
  申请人：——

  公开号：US20030207924A1

  公开（公告）日：2003-11-06

  This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses methods for making the disclosed compounds.

  这项发明揭示了能够改变PPAR活性的化合物。该发明还揭示了这些化合物的药用盐、包含这些化合物或其盐的药用组合物，以及将它们用作治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。本发明还揭示了制备所述化合物的方法。
• [EN] SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1)<br/>[FR] DERIVES DE NAPHTHYL INDOLE SUBSTITUES UTILISES COMME INHIBITEURS DE L'INHIBITEUR DES ACTIVATEURS DU PLASMINOGENE DE TYPE-1 (PAI-1)
  申请人：WYETH CORP

  公开号：WO2003000684A1

  公开（公告）日：2003-01-03

  This invention provides PAI-1 inhibiting compounds of Formula (I): wherein: R1, R2, R3 and R4 are eachH, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; R5 is H, alkyl perfluoroalkyl, aryl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8, R6 is H, alkyl, alkylaryl, benzyl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8, R7 is H, alkyl, alkylaryl, aryl optionally substituted with R8, n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO3H, PO3H2, tetronic acid, etc.; R8 is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.

  此发明提供了PAI-1抑制剂化合物的公式（I）：其中：R1、R2、R3和R4分别为H、烷基、烷酰基、卤、OH、取代有R8的芳基、全氟烷基、烷氧基、氨基、烷基氨基、二烷基氨基、全氟烷氧基；R5为H、烷基、全氟烷基、取代有R8的芳基、烷酰基、取代有R8的芳酰基；R6为H、烷基、烷基芳基、取代有R8的苄基、烷酰基、取代有R8的芳酰基；R7为H、烷基、烷基芳基、取代有R8的芳基、n为0-6；A为COOH或如四唑、SO3H、PO3H2、四酮酸等酸类类似物；R8为H、烷基、环烷基、烷酰基、卤、OH、全氟烷基、烷氧基、氨基、烷基氨基、二烷基氨基、全氟烷氧基；或其药学上可接受的盐；以及使用这些化合物的药物组合物和治疗方法。
• SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1)
  申请人：Wyeth

  公开号：EP1397356A1

  公开（公告）日：2004-03-17
• THIAZOLE AND OXAZOLE DERIVATIVES WHICH MODULATE PPAR ACTIVITY
  申请人：Warner-Lambert Company LLC

  公开号：EP1482935A1

  公开（公告）日：2004-12-08
• [EN] THIAZOLE AND OXAZOLE DERIVATIVES WHICH MODULATE PPAR ACTIVITY<br/>[FR] DERIVES DE THIAZOLE ET D'OXAZOLE QUI MODULENT L'ACTIVITE DE PPAR
  申请人：WARNER LAMBERT CO

  公开号：WO2003074050A1

  公开（公告）日：2003-09-12

  This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses methods for making the disclosed compounds.