2-(4-chlorophenyl)-1-(diphenylmethyl)-4,4-dimethyl-4,5-dihydro-1H-imidazole | 1253480-97-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-chlorophenyl)-1-(diphenylmethyl)-4,4-dimethyl-4,5-dihydro-1H-imidazole
• 英文别名: 3-benzhydryl-2-(4-chlorophenyl)-5,5-dimethyl-4H-imidazole
• CAS: 1253480-97-5
• 化学式: C₂₄H₂₃ClN₂
• 分子量: 374.913
• InChiKey: IGLFUYZVHSJVQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] 2-ARYL IMIDAZOLINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2-ARYL IMIDAZOLINE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010123150A1

  公开（公告）日：2010-10-28

  2-Aryl imidazoline derivatives are provided that are useful as anti-obesity agents or the like. A compound represented by Formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each independently represent a hydrogen atom, halogen, C1-6alkyl, or the like; R3a, R3b, R4a and R4b each independently represent a hydrogen atom, C1-6alkyl, or haloC1-6alkyl; and Ar represents aryl, wherein the aryl may be substituted with 1 to 3 substituents such as halogen, cyano, C1-6alkyl, haloC1-6alkyl, C1-6alkyloxy, haloC1-6alkyloxy, hydroxy, amino, monoC1-6alkylamino, diC1-6alkylamino, and C1-6alkyloxycarbonyl.

  提供了2-芳基咪唑啉衍生物，可用作抗肥胖剂或类似物。化合物由式（I）或其药学上可接受的盐表示：其中R1和R2各自独立地表示氢原子，卤素，C1-6烷基或类似物；R3a，R3b，R4a和R4b各自独立地表示氢原子，C1-6烷基或卤代C1-6烷基；Ar表示芳基，其中芳基可以用1至3个取代基如卤素，氰基，C1-6烷基，卤代C1-6烷基，C1-6烷氧基，卤代C1-6烷氧基，羟基，氨基，单C1-6烷基氨基，双C1-6烷基氨基和C1-6烷氧羰基进行取代。
• 2-ARYL IMIDAZOLINE DERIVATIVES
  申请人：Haga Yuji

  公开号：US20120029041A1

  公开（公告）日：2012-02-02

  2-Aryl imidazoline derivatives are provided that are useful as anti-obesity agents or the like. A compound represented by Formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 and R 2 each independently represent a hydrogen atom, halogen, C 1-6 alkyl, or the like; R 3a , R 3b , R 4a and R 4b each independently represent a hydrogen atom, C 1-6 alkyl, or haloC 1-6 alkyl; and Ar represents aryl, wherein the aryl may be substituted with 1 to 3 substituents such as halogen, cyano, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkyloxy, haloC 1-6 alkyloxy, hydroxy, amino, monoC 1-6 alkylamino, diC 1-6 alkylamino, and C 1-6 alkyloxy-carbonyl.

  提供了用作抗肥胖剂或类似药物的2-芳基咪唑啉衍生物。化合物的表示式为（I）或其药学上可接受的盐： 其中R1和R2各自独立地表示氢原子、卤素、C1-6烷基或类似物；R3a、R3b、R4a和R4b各自独立地表示氢原子、C1-6烷基或卤代C1-6烷基；Ar表示芳基，其中芳基可以用1至3个取代基如卤素、氰基、C1-6烷基、卤代C1-6烷基、C1-6烷氧基、卤代C1-6烷氧基、羟基、氨基、单C1-6烷基氨基、双C1-6烷基氨基和C1-6烷氧基羰基进行取代。