N-((6-(cyclopropylamino)pyridin-3-yl)methyl)-N-(4-fluorophenyl)-2,2-dimethylpropionamide | 1033863-35-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-((6-(cyclopropylamino)pyridin-3-yl)methyl)-N-(4-fluorophenyl)-2,2-dimethylpropionamide
• 英文别名: N-[[6-(cyclopropylamino)pyridin-3-yl]methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide
• CAS: 1033863-35-2
• 化学式: C₂₀H₂₄FN₃O
• 分子量: 341.428
• InChiKey: JFVPXLDWHGRSCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ION CHANNEL MODULATORS
  申请人：Galullo Vincent P.

  公开号：US20100267697A1

  公开（公告）日：2010-10-21

  The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R 1 , R 2 , R 3 , p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

  本教材提供公式(I)化合物及其药学上可接受的盐、水合物和酯，其中Ar、R1、R2、R3、p和X在此定义。本教材还提供生产所述化合物及其药学上可接受的盐、水合物和酯的方法，以及使用所述化合物及其药学上可接受的盐、水合物和酯治疗病理状况或障碍，或减轻其症状的方法。该化合物可用于调节离子通道活性，包括治疗与一个或多个电压门控钙离子通道异常调节相关的各种疾病。
• [EN] ION CHANNEL MODULATORS<br/>[FR] MODULATEURS DE CANAL IONIQUE
  申请人：WYETH CORP

  公开号：WO2008073929A1

  公开（公告）日：2008-06-19

  [EN] The present teachings provide compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R¹, R², R³, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.
  [FR] La présente invention concerne des composés de formule (I) et des sels, hydrates et esters pharmaceutiquement acceptables de ceux-ci, où Ar, R¹, R², R³, p et X sont définis ici. La présente invention concerne également des procédés de production desdits composés et de leurs sels, hydrates et esters pharmaceutiquement acceptables, et des procédés de traitement d'une affection ou d'un trouble pathologique, ou de soulagement d'un symptôme de ceux-ci, en utilisant lesdits composés comprenant leurs sels, hydrates et esters pharmaceutiquement acceptables. Les composés peuvent être utiles dans la modulation de l'activité de canal ionique comprenant le traitement d'une variété d'affections associées à la modulation anormale d'un canal calcique dépendant d'un potentiel d'action ou plus.