N-Methyl-N'-(3-trifluormethyl)phenethylpiperazin | 51353-20-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Methyl-N'-(3-trifluormethyl)phenethylpiperazin
• 英文别名: 1-methyl-4-(3-trifluoromethyl-phenethyl)-piperazine；1-Methyl-4-[2-[3-(trifluoromethyl)phenyl]ethyl]piperazine
• CAS: 51353-20-9
• 化学式: C₁₄H₁₉F₃N₂
• 分子量: 272.313
• InChiKey: RFUXHXGJNFNVCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE<br/>[FR] DERIVES DE PHENYLPIPERAZINE CYCLOALCANOL ET METHODES D'UTILISATION ASSOCIEES
  申请人：WYETH CORP

  公开号：WO2005037808A1

  公开（公告）日：2005-04-28

  The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibrornyalgia, pain, diabetic neuropathy, and combinations thereof.

  本发明涉及苯基哌嗪环丙醇衍生物，含有这些衍生物的组合物，以及它们用于预防和治疗由单胺再摄取改善的病症的方法，包括但不限于血管运动症状（VMS）、性功能障碍、胃肠道和泌尿系统疾病、慢性疲劳综合征、纤维肌痛综合征、神经系统疾病等，以及从主要抑郁症、血管运动症状、压力性和切勿性尿失禁、纤维肌痛、疼痛、糖尿病神经病变等病症组合中选择的特定病症的组合。
• PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE
  申请人：Wyeth

  公开号：EP1673358A1

  公开（公告）日：2006-06-28
• SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
  申请人：The Regents of the University of Michigan

  公开号：US20160304485A1

  公开（公告）日：2016-10-20

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.