(S)-2-methylpropane-2-sulfinic acid [(R)-phenyl-p-tolylmethyl]amide | 851513-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-methylpropane-2-sulfinic acid [(R)-phenyl-p-tolylmethyl]amide
• 英文别名: (S)-2-methyl-N-((R)-phenyl(p-tolyl)methyl)propane-2-sulfinamide；(S)-2-methyl-N-[(R)-(4-methylphenyl)-phenylmethyl]propane-2-sulfinamide
• CAS: 851513-53-6
• 化学式: C₁₈H₂₃NOS
• 分子量: 301.453
• InChiKey: RBDGPASCSKSXMS-UTKZUKDTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  48.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-2-methylpropane-2-sulfinic acid [(R)-phenyl-p-tolylmethyl]amide 在 盐酸 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 1.0h， 生成 (α¹R)-4-methyl-α-phenyl-benzenemethanamine hydrochloride
  参考文献：
  名称：

  WO2007/104162

  摘要：

  公开号：
• 作为产物：
  描述：

  4-甲苯硼酸 、 (S,E)-N-benzylidene-tert-butylsulfinamide 在 bis(acetonitrile)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 三乙胺 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 48.0h， 以81%的产率得到
  参考文献：
  名称：

  WO2007/104162

  摘要：

  公开号：

文献信息

• A Room-Temperature Protocol for the Rhodium(I)-Catalyzed Addition of Arylboron Compounds to Sulfinimines
  作者：Yuri Bolshan、Robert A. Batey

  DOI：10.1021/ol050014f

  日期：2005.4.14

  of organoboronic acids to chiral sulfinimines proceeds under mild conditions at room temperature, using Rh(I) catalysis in the absence of external phosphine ligands. Clean reaction only occurs in the presence of water as a cosolvent. The sulfinamide adducts are formed with high diastereoselectivities, providing a convenient route to the synthesis of enantiomerically enriched chiral benzylic amines.

  [反应：见正文]在室温下，在不存在外部膦配体的情况下，使用Rh（I）催化，在温和条件下，将有机硼酸添加到手性亚磺胺中。清洁反应仅在水作为助溶剂存在下发生。形成的亚磺酰胺加合物具有高非对映选择性，为合成对映异构体富集的手性苄胺提供了便利的途径。
• Synthesis of Benzhydryl-Substituted Amines by Silanolate-Mediated Aldimine Arylation with Functionalized Aryl Nucleophiles Released from Diazene-Based Reagents
  作者：Aliyaah J. M. Rahman、Lucie Finck、Wolfgang Obermayer、Martin Oestreich

  DOI：10.1021/acs.orglett.2c03798

  日期：2022.12.16

  imine derivatives with functionalized aryl pronucleophiles is reported. The aryl nucleophiles are released from silicon-protected aryl-substituted diazenes by desilylation with potassium trimethylsilanolate concomitant with the loss of dinitrogen. A broad range of functional groups is tolerated in the aryl nucleophile but, depending upon their electronic effect, require specific groups at the imine

  报道了一种无过渡金属的方案，用于N -苯基 - 和N -苯甲酰基取代的苯甲醛衍生亚胺衍生物与功能化芳基亲核试剂的芳基化。芳基亲核试剂通过用三甲基硅烷醇钾进行脱甲硅烷基化并伴随二氮的损失从硅保护的芳基取代的二氮烯中释放出来。芳基亲核试剂可容许多种官能团，但根据它们的电子效应，亚胺氮原子上需要特定的基团。
• IAP BIR DOMAIN BINDING COMPOUNDS
  申请人：Aegera Therapeutics Inc.

  公开号：EP2004600A1

  公开（公告）日：2008-12-24
• IAP bir domain binding compounds
  申请人：Boudreault Alain

  公开号：US20080069812A1

  公开（公告）日：2008-03-20

  Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R 1 , R 2 , R 3 , R 100 , R 200 , R 300 , A, A 1 , BG, Q and Q 1 are substituents described herein. Also disclosed is the use of compounds of Formula I and II to treat proliferative disorders such as cancer.
• IAP BIR domain binding compounds
  申请人：Boudreault Alain

  公开号：US20080207525A1

  公开（公告）日：2008-08-28

  Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R 1 , R 2 , R 3 , R 100 , R 200 , R 300 , A, A 1 , BG, Q and Q 1 are substituents described herein. Also disclosed is the use of compounds of Formula I and II to treat proliferative disorders such as cancer.