3-(1-cyano-1-methylethoxy)benzoic acid 、
N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide 在
吡啶 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下,
反应 1.0h,
以48%的产率得到N-[5-[(2-acetamido-[1,3]thiazolo[5,4-b]pyridin-5-yl)-methylamino]-2-fluorophenyl]-3-(2-cyanopropan-2-yloxy)benzamide