erismodegib | 1221721-91-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: erismodegib
• 英文别名: 4'-methoxy-2-methylbiphenyl-3-carboxylic acid [6-((2R,6S)-2,6-dimethylmorpholin-4-yl)pyridin-3-yl]amide；N-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-3-(4-methoxyphenyl)-2-methylbenzamide
• CAS: 1221721-91-0
• 化学式: C₂₆H₂₉N₃O₃
• 分子量: 431.535
• InChiKey: ZFLKXHWZMNHRHN-HDICACEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• BIPHENYLCARBOXAMIDE DERIVATIVES AS HEDGEHOD PATHWAY MODULATORS
  申请人：Dierks Christine

  公开号：US20100197659A1

  公开（公告）日：2010-08-05

  The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

  该发明提供了一种调节刺猬信号通路活性的方法。具体来说，该发明提供了一种抑制由于Ptc功能丧失、刺猬功能增强、smoothened功能增强或Gli功能增强等表型引起的异常生长状态的方法，包括将细胞与化合物I式的足够量接触。
• COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS
  申请人：Gao Wenqi

  公开号：US20090203666A1

  公开（公告）日：2009-08-13

  The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

  本发明提供了一种调节刺猬信号通路活性的方法。具体而言，本发明提供了一种通过接触细胞与化合物I的足够量来抑制由于Ptc功能缺失、刺猬功能增强、平滑蛋白功能增强或Gli功能增强等表型引起的异常生长状态的方法。
• [EN] PROCESS FOR THE PREPARATION OF N-[6-(CIS-2,6-DIMETHYLMORPHOLIN-4-YL)PYRIDINE-3-YL]-2- METHYL-4'-(TRIFIUOROMETHOXY) [1,1' -BIPHENYI]-3-CARBOXAMIDE AND ITS POLYMORPHS THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE N-[6-(CIS-2,6-DIMÉTHYLMORPHOLIN-4-YL)PYRIDINE-3-YL]-2- MÉTHYL-4'-(TRIFLUOROMÉTHOXY) [1,1'-BIPHÉNYL]-3-CARBOXAMIDE ET DE SES POLYMORPHES
  申请人：MSN LABORATORIES PRIVATE LTD

  公开号：WO2017163258A1

  公开（公告）日：2017-09-28

  The present invention relates to process for the preparation of N-[6-(cis-2,6-dimethyl morpholin-4-yl)pyridine-3-yl]-2-methyl-4' -(trifluoromethoxy) [1,1'-biphenyl]-3-carboxamide compound of formula-1, it's salts and their polymorphs thereof.

  本发明涉及一种制备N-[6-(顺-2,6-二甲基吗啉-4-基)吡啶-3-基]-2-甲基-4'-三氟甲氧基[1,1'-联苯]-3-羧酰胺化合物（式-1）、其盐及其多晶形的方法。
• BLOCK COPOLYMERS FOR STABLE MICELLES
  申请人：Intezyne Technologies, Inc.

  公开号：US20140113879A1

  公开（公告）日：2014-04-24

  The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
• IRON STABILIZED MICELLES AS MAGNETIC CONTRAST AGENTS
  申请人：Intezyne Technologies

  公开号：US20160346408A1

  公开（公告）日：2016-12-01

  The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and iron stabilized micelles comprising the same, as magnetic contrast agents. Compositions herein are useful for diagnostic and drug-delivery applications.