4-N-[3-[6-[2-(3,4-dimethoxyphenyl)ethoxy]pyridin-2-yl]phenyl]piperidine-1,4-dicarboxamide | 1185999-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-N-[3-[6-[2-(3,4-dimethoxyphenyl)ethoxy]pyridin-2-yl]phenyl]piperidine-1,4-dicarboxamide
• CAS: 1185999-23-8
• 化学式: C₂₈H₃₂N₄O₅
• 分子量: 504.586
• InChiKey: HDJQSMNFFBKHHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• COMPOUND HAVING 6-MEMBERED AROMATIC RING
  申请人：Setoh Masaki

  公开号：US20110009421A1

  公开（公告）日：2011-01-13

  An object of the present invention is to provide an agent for preventing or treating schizophrenia or the like, wherein the compound of the present invention has GPRS2 agonist activity. [Means] A compound represented by the following formula (I) or salt thereof: wherein A represents —(CH 2 ) n —CO—NR a — (n is an integer of 0 to 3) or —NR a —CO—, B represents a hydrogen atom, halogen atom, cyano group, hydroxy group, or the like, X 1 , X 2 , X 3 , and X 4 represent the same or different —CR x ═, or —N═, Y represents —O—, —S—, —S(O)—, —S(O) 2 —, or —NR y —, Z represents a bond, methylene, or ethylene, Ar 1 represents a five- to ten-membered aromatic ring (except for thiazole) which may be substituted with one or more substituents selected from halogen atoms, optionally halogenated C 1-6 alkyl groups, and the like, Ar 2 represents a five- to six-membered aromatic ring which may be substituted with one or more substituents selected from halogen atoms, optionally halogenated C 1-6 alkyl groups, and the like, and which may be condensed with an optionally substituted five- to six-membered ring, and R a , R b , R x , and R y represent the same or different hydrogen atom, halogen atoms, or the like].

  本发明的目的是提供一种用于预防或治疗精神分裂症等疾病的药剂，其中本发明的化合物具有GPRS2激动剂活性。[手段]以下式(I)或其盐所表示的化合物：其中A代表—(CH2)n—CO—NRa—(n为0至3的整数)或—NRa—CO—，B代表氢原子、卤原子、氰基、羟基等，X1、X2、X3和X4代表相同或不同的—CRx═或—N═，Y代表—O—、—S—、—S(O)—、—S(O)2—或—NRy—，Z代表键、亚甲基或乙烯基，Ar1代表一个五至十元环芳香环(除噻唑外)，可以被一个或多个卤原子、可选卤代C1-6烷基等取代，Ar2代表一个五至六元环芳香环，可以被一个或多个卤原子、可选卤代C1-6烷基等取代，可以与一个可选取代的五至六元环融合，并且Ra、Rb、Rx和Ry代表相同或不同的氢原子、卤原子等。