申请人:NIPPON CHEMIPHAR CO., LTD.
公开号:EP0326379A2
公开(公告)日:1989-08-02
A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula:
wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 3, or its pharmaceutically acceptable salt is diclosed.
一种肝病治疗剂,其有效成分为
哌嗪衍
生物,其式如下
其中,A 代表
苯基、
对苯醌基或
积雪草苷基,可具有至少一个选自卤素、烷基、
氟烷基、甲酰基、烷
氧羰基、酰基、羟基、烷
氧基、酰
氧基、糖
氧基、
氨基、烷基
氨基、巯基、烷
硫基和硝基的取代基;B 代表单键或含有 1-4 个
碳原子的直链亚烷基,该亚烷基可具有至少一个选自烷基、芳基、芳烷基、羟基和
氧代的取代基;R 代表一个原子或一个选自
氢、碱
金属、碱土
金属、烷基、
环烷基、芳烷基和芳基的基团;且 n 为 2 或 3,或其药学上可接受的二缩盐。