2-Amino-3,4-dimethoxy-benzamide | 19178-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-3,4-dimethoxy-benzamide
• 英文别名: 2-Amino-3,4-dimethoxybenzamide
• CAS: 19178-34-8
• 化学式: C₉H₁₂N₂O₃
• 分子量: 196.206
• InChiKey: WDJVHPVTQAHQDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  87.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY
  申请人：Denny William Alexander

  公开号：US20090318479A1

  公开（公告）日：2009-12-24

  The present invention relates to substituted ring fused azines and methods of using said compounds in treating cancers. More specifically, the present invention relates to the preparation of 4-alkyl-2-(heterocyclic)-azines and their use as cancer agents or drugs for cancer therapy. The compounds of the invention display favourable in vivo and in vitro activity against selected cancers.

  本发明涉及取代环融合吡嗪类化合物及其在治疗癌症中的使用方法。更具体地说，本发明涉及制备4-烷基-2-(杂环)-吡嗪类化合物及其作为癌症治疗药物或药剂的使用。本发明的化合物在体内和体外对选定的癌症表现出良好的活性。
• PROCESSES FOR THE SYNTHESIS OF 2-AMINO-4,6-DIMETHOXYBENZAMIDE AND OTHER BENZAMIDE COMPOUNDS
  申请人：Albemarle Corporation

  公开号：EP2906530A1

  公开（公告）日：2015-08-19
• [EN] TREATMENT OF DISEASES BY EPIGENETIC REGULATION<br/>[FR] TRAITEMENT DE MALADIES PAR LA RÉGULATION ÉPIGÉNÉTIQUE
  申请人：RVX THERAPEUTICS INC

  公开号：WO2013156869A1

  公开（公告）日：2013-10-24

  The present application is directed to the use of substituted 2-phenyl-3H-quinazolin-4-ones and analogs for inhibiting BET (bromodomain and extra terminal domain) proteins. The disclosed compounds can be used for the treatment of cancers that exhibit c-myc overexpression, cancers that overexpress n-myc, and cancers that rely on the recruitment of p-TEFb to regulate activated oncogenes, such as Burkitt's lymphoma, acute myelogenous leukemia, multiple myeloma, aggressive human medulloblastoma, hematological, epithelial cancers, lung cancers, breast cancers, colon carcinomas, midline carcinomas, mesenchymal tumors, hepatic tumors, renal tumors and neurological tumors. Other diseases or disorders that can be treated with the disclosed compounds include autoimmune or inflammatory diseases or conditions, diseases or disorders caused by bacterial or viral infection.
• [EN] PROCESSES FOR THE SYNTHESIS OF 2-AMINO-4,6-DIMETHOXYBENZAMIDE AND OTHER BENZAMIDE COMPOUNDS<br/>[FR] PROCÉDÉS DE SYNTHÈSE DE 2-AMINO-4,6-DIMÉTHOXYBENZAMIDE ET D'AUTRES COMPOSÉS DE BENZAMIDE
  申请人：ALBEMARLE CORP

  公开号：WO2014062428A1

  公开（公告）日：2014-04-24

  This invention provides a method for the synthesis of a 2-amino-4,6-dimethoxybenzamide and other benzamides of Compound I: wherein R1, R2, R3, and R4 each independently represent a hydrogen, a C1-C6 alkyl, or a C1-C6 alkoxy; and wherein R6 and R7 each independently represent a hydrogen, a C1-C6 alkyl, a protecting group, or a directing group.