4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate | 1437798-92-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate
• 英文别名: 4-ethyl 3-isopropyl 5-acetyl-1,4-dihydro-1-(4-methoxyphenyl)-2,6-dimethylpyridine-3,4-dicarboxylate；4-O-ethyl 3-O-propan-2-yl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-4H-pyridine-3,4-dicarboxylate
• CAS: 1437798-92-9
• 化学式: C₂₃H₂₉NO₆
• 分子量: 415.486
• InChiKey: JVAZARIOSNTXLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  甲氧苯胺 在 montmorillonite K-10 作用下， 反应 6.0h， 生成 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate
  参考文献：
  名称：

  Multicomponent reactions leading to symmetric and asymmetric multi-substituted 1,4-dihydropyridines on montmorillonite

  摘要：

  Highly functionalized multi-substituted symmetric and asymmetric 1,4-dihydropyridines were concisely synthesized in moderate to good yields via one-pot multicomponent reactions (MCRs) of beta-dicarbonyl compounds, aldehydes and amines at room temperature on montmorillonite. The merits of this method include the environmentally friendly reaction conditions, simple operation, broad substrate, satisfied yields and the reuse of the montmorillonite. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.04.006

文献信息

• Copper-Catalyzed Aerobic Cascade Oxidative Coupling/Cyclization for the Construction of 1,4-Dihydropyridine Derivatives
  作者：Zhi-Qiang Zhu、Zong-Bo Xie、Zhang-Gao Le

  DOI：10.1021/acs.joc.6b01736

  日期：2016.10.7

  An efficient copper-catalyzed cascade cyclization reaction for the preparation of polysubstituted 1,4-dihydropyridines between N-arylglycine esters and 1,3-dicarbonyl compounds using molecular oxygen as the terminal oxidant has been described. Various N-arylglycine esters 1 and 1,3-dicarbonyl compounds 2 were able to undergo the cascade reaction smoothly to afford the desired products 3 in satisfactory

  已经描述了一种有效的铜催化的级联环化反应，该反应使用分子氧作为末端氧化剂在N-芳基甘氨酸酯和1,3-二羰基化合物之间制备多取代的1,4-二氢吡啶。各种N-芳基甘氨酸酯1和1，3-二羰基化合物2能够顺利地进行级联反应，以令人满意的产率得到所需的产物3。级联反应具有良好的官能团耐受性和温和的反应条件的优点。在控制实验的基础上，还提出了一种可能的机制。