2-formylpyridine-4-(2,6-dimethylphenyl)thiosemicarbazone | 1416265-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-formylpyridine-4-(2,6-dimethylphenyl)thiosemicarbazone
• 英文别名: 2-Formylpyridine 4-(2,6-dimethyl-phenyl)thiosemicarbazone；1-(2,6-dimethylphenyl)-3-(pyridin-2-ylmethylideneamino)thiourea
• CAS: 1416265-47-8
• 化学式: C₁₅H₁₆N₄S
• 分子量: 284.385
• InChiKey: KWZWFRMBOZFCGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  copper(II) choride dihydrate 、 2-formylpyridine-4-(2,6-dimethylphenyl)thiosemicarbazone 以 乙醇 为溶剂， 以70%的产率得到di(μ-S)-bis{chloro-[2-picolidene-4-(2,6-dimethylphenyl)thiosemicarbazido]copper}tetrahydrate
  参考文献：
  名称：

  Coordination compounds of copper with 2-formylpyridine 4-(dimethylphenyl)thiosemicarbazones

  摘要：

  2-Formylpyridine 4-(2,6-dimethylphenyl)-(HL1), 4-(2,5-dimethylphenyl)-(HL2), 4-(3,4-dimethylphenyl)-(HL3), and 4-(2,4-dimethylphenyl)thiosemicarbazones (HL4) react with copper chloride and nitrate to form coordination compounds CuL1-4X center dot nH(2)O [X = Cl-, NO (3) (-) ; n = 1, 2]. All compounds have a polynuclear structure. Azomethines HL1-4 act as the bridging monodeprotonated tridentate N,N,S-ligands. The thermolysis of the complexes includes the dehydration (70-90A degrees C) and total thermal decomposition (350-520A degrees C). The complexes synthesized exhibit a selective antimicrobial activity against a series of standard strains of Staphylococcus aureus and Escherichia coli in the concentration range of 0.009-37.5 mu g ml(-1).

  DOI：

  10.1134/s1070363212110242