6-bromo-8-methoxy-2-methylimidazo[1,2-a]pyridine | 1524992-94-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 6-bromo-8-methoxy-2-methylimidazo[1,2-a]pyridine
• CAS: 1524992-94-6
• 化学式: C₉H₉BrN₂O
• 分子量: 241.087
• InChiKey: WMUCELFRFQFVTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-bromo-8-methoxy-2-methylimidazo[1,2-a]pyridine 在 ammonium carbonate 、 氮 、 potassium carbonate 作用下， 生成 6-(8-methoxy-2-methylimidazo[1,2-a]pyridin-6-yl)-2-(1-methylpiperidin-4-yl)-3H-quinazolin-4-one
  参考文献：
  名称：

  Substituted pyrazolo[1,5-a]pyrazines for spinal muscular atrophy

  摘要：

  A prophylactic or therapeutic agent for spinal muscular atrophy according to the present invention includes a compound represented by the formula (I) or a salt thereof: the variables are described herein.

  公开号：

  US12012410B2
• 作为产物：
  描述：

  2-氨基-3-甲氧基-5-溴吡啶 、 1-溴-2,2-二甲氧基丙烷 在 4-甲基苯磺酸吡啶 作用下， 以 异丙醇 为溶剂， 反应 5.0h， 以96%的产率得到6-bromo-8-methoxy-2-methylimidazo[1,2-a]pyridine
  参考文献：
  名称：

  [EN] HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
  [FR] MODULATEURS HTT POUR LE TRAITEMENT DE LA MALADIE DE HUNTINGTON

  摘要：

  以下提供了一些作为HTT调节剂有用的化合物。这些化合物在亨廷顿病的治疗中很有用。

  公开号：

  WO2021231571A1

文献信息

• HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
  申请人：CHDI Foundation, Inc.

  公开号：US20220409615A1

  公开（公告）日：2022-12-29

  Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
• [EN] PRMT5 INHIBITORS<br/>[FR] INHIBITEURS DE PRMT5
  申请人：MERCK SHARP & DOHME

  公开号：WO2021126729A1

  公开（公告）日：2021-06-24

  The present invention provides a compound of Formula (I) (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
• [EN] 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME<br/>[FR] DÉRIVÉS D'ACÉTAMIDO-PHÉNYLTÉTRAZOLE ET LEURS MÉTHODES D'UTILISATION
  申请人：[en]RGENTA THERAPEUTICS, INC.

  公开号：WO2023102231A1

  公开（公告）日：2023-06-08

  The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds of the present disclosure may act as small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded genes, and methods of use of the compounds for modulating splicing and treating related diseases and conditions. The compounds disclosed herein may possess activity toward various genetic pathways and are accordingly useful in methods of treatment of the human or animal body.
• WO2023/34811
  申请人：——

  公开号：——

  公开（公告）日：——