(R)-3-异丙氧基吡咯烷 | 1187932-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: (R)-3-异丙氧基吡咯烷
• 英文名称: (R)-3-Isopropoxypyrrolidine
• 英文别名: (3R)-3-propan-2-yloxypyrrolidine
• CAS: 1187932-43-9
• 化学式: C₇H₁₅NO
• mdl: MFCD11858551
• 分子量: 129.2
• InChiKey: IYKVTPKGWBIZFR-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
  申请人：Merck Patent GmbH

  公开号：US20160376283A1

  公开（公告）日：2016-12-29

  The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

  本发明涉及式I化合物及其药用可接受的组合物，用作TBK/IKKε抑制剂。
• Hybrid Compounds And Methods Of Making And Using The Same
  申请人：Pan Wenxi

  公开号：US20140171438A1

  公开（公告）日：2014-06-19

  The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.

  本公开提供化合物或其药学上可接受的盐，用于抑制微生物的生长；治疗患有微生物感染、疟疾、粘膜炎、眼部感染、耳部感染、癌症或分枝杆菌感染的哺乳动物；杀灭或抑制疟原虫的生长；抑制分枝杆菌的生长；调节哺乳动物的免疫反应；或对抗非分馏肝素、低分子量肝素或肝素/低分子量肝素衍生物。
• ISOINDOLONES DERIVATIVES AS MEK KINASE INHIBITORS AND METHODS OF USE
  申请人：Gancia Emanuela

  公开号：US20110124622A1

  公开（公告）日：2011-05-26

  The invention relates to isoindolones of formula, (I) with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  本发明涉及公式（I）的异吲哚酮，具有抗癌和/或抗炎活性，更具有MEK激酶抑制活性。本发明提供了用于抑制异常细胞生长，治疗增生性疾病或治疗哺乳动物炎症性疾病的组合物和方法。本发明还涉及使用该化合物进行哺乳动物细胞的体外，体内和原位诊断或治疗，或相关病理条件的方法。
• TBK/IKK inhibitor compounds and uses thereof
  申请人：Merck Patent GmbH

  公开号：US10428080B2

  公开（公告）日：2019-10-01

  The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

  本发明涉及可用作 TBK/IKKε 抑制剂的式 I 化合物及其药学上可接受的组合物。
• AMINO-PYRAZINECARBOXAMIDE COMPOUNDS, CONJUGATES, AND USES THEREOF
  申请人：Silverback Therapeutics, Inc.

  公开号：US20220362396A1

  公开（公告）日：2022-11-17

  Amino-pyrazinecarboxamide compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGFβR2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.