2-chloro-6-fluoro-N-(5-(2-methyl-5-(pyridin-3-yl)phenyl)pyridin-2-yl)benzamide hydrochloric acid salt | 1113042-61-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-chloro-6-fluoro-N-(5-(2-methyl-5-(pyridin-3-yl)phenyl)pyridin-2-yl)benzamide hydrochloric acid salt
• 英文别名: 2-chloro-6-fluoro-N-(5-(2-methyl-5-(pyridin-3-yl)phenyl)pyridin-2-yl)benzamide hydrochloride；2-chloro-6-fluoro-N-[5-(2-methyl-5-pyridin-3-ylphenyl)pyridin-2-yl]benzamide;hydrochloride
• CAS: 1113042-61-7
• 化学式: C₂₄H₁₇ClFN₃O*ClH
• 分子量: 454.331
• InChiKey: HORGALVLQGVBLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.59
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  54.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES<br/>[FR] COMPOSÉS PYRIDINE UTILISÉS POUR DES ÉTATS INFLAMMATOIRES ET DES TROUBLES IMMUNITAIRES
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2009017819A1

  公开（公告）日：2009-02-05

  The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

  这项发明涉及一类可用作免疫抑制剂、用于治疗和预防炎症性疾病、过敏性疾病和免疫性疾病的化合物。
• PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
  申请人：Chen Shoujun

  公开号：US20120064121A1

  公开（公告）日：2012-03-15

  The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

  这项发明涉及一类可用作免疫抑制剂以及用于治疗和预防炎症性疾病、过敏性疾病和免疫性疾病的化合物。
• Radiation-sensitive resin composition
  申请人：JSR Corporation

  公开号：EP1164433A1

  公开（公告）日：2001-12-19

  A positive-type radiation-sensitive resin composition is provided. The composition includes: (A) a low-molecular compound comprising a compound having at least one amino group having one or two hydrogen atom(s) bonded to the nitrogen atom; at least one hydrogen atom the amino group has having been substituted with a t-butoxycarbonyl group; (B) a radiation-sensitive acid generator; and (C) a silicon-atom-containing resin comprising an alkali-insoluble or alkali-slightly-soluble resin having been protected with an acid-cleavable group; the resin being capable of turning soluble in alkali upon cleavage of the acid-cleavable group. This radiation-sensitive resin composition is effectively responsive to radiations of various types, has superior sensitivity and resolution and also a superior long-term storage stability, and is useful as a positive-type chemically amplified resist.

  提供了一种正型辐射敏感树脂组合物。该组合物包括 (A) 一种低分子化合物，该化合物含有至少一个氨基，氨基上有一个或两个氢原子与氮原子结合；氨基上的至少一个氢原子被一个叔丁氧羰基取代； (B) 辐射敏感酸发生器；以及 (C) 含硅原子的树脂，该树脂由碱不溶性或碱微溶性树脂组成，并用酸可裂解基团保护；该树脂在酸可裂解基团裂解后可溶于碱。这种辐射敏感树脂组合物能有效地对各种类型的辐射做出反应，具有极高的灵敏度和分辨率，以及极佳的长期储存稳定性，可用作正型化学放大抗蚀剂。
• VINYLPHENYLPROPIONIC ACID DERIVATIVES, PROCESSES FOR PRODUCTION OF THE DERIVATIVES, POLYMERS THEREOF AND RADIOSENSITIVE RESIN COMPOSITIONS
  申请人：JSR Corporation

  公开号：EP1231205A1

  公开（公告）日：2002-08-14

  Vinylphenylpropionic acid derivatives; processes for producing the derivatives; polymers of the same; and radiosensitive resin compositions containing the polymers. The above polymers exhibit low radiation absorption and are useful as the resin component of radiosensitive resin compositions particularly suitable for chemically amplified resists. For example, t-butyl 4-vinylphenylpropionate is produced by (1) reacting t-butyl bromoacetate with tri(n-butyl)phosphine to obtain a quaternary phosphonium salt, (2) reacting this salt with a base to obtain a phosphorus ylide, (3) reacting this ylide with 2,4,6-tris(3',5'-di-t-butyl-4'-hydroxybenzyl)methyl-styrene to obtain a quaternary phosphonium salt, and (4) hydrolyzing this salt.

  乙烯基苯丙酸衍生物；生产该衍生物的工艺；该衍生物的聚合物；以及含有该聚合物的辐射敏感树脂组合物。上述聚合物的辐射吸收率低，可用作辐射敏感树脂组合物的树脂成分，尤其适用于化学放大抗蚀剂。例如，4-乙烯基苯基丙酸叔丁酯是通过以下方法制得的：(1) 将溴乙酸叔丁酯与三(正丁基)膦反应，得到季鏻盐、(2) 将这种盐与碱反应，得到一种磷酰亚胺； (3) 将这种酰亚胺与 2,4,6-三（3',5'-二-叔丁基-4'-羟基苄基）甲基苯乙烯反应，得到一种季鏻盐； (4) 将这种盐水解。
• Curable composition, film, and method of producing film
  申请人：CANON KABUSHIKI KAISHA

  公开号：US10208183B2

  公开（公告）日：2019-02-19

  Provided is a curable composition, including a polymerization initiator; a polymerizable compound; and an internal addition type release agent having a hydrophilic functional group, in which the internal addition type release agent is prevented from being unevenly distributed in a gas-liquid interface of the curable composition.

  本发明提供了一种可固化组合物，包括聚合引发剂、可聚合化合物和具有亲水官能团的内加成型脱模剂，其中内加成型脱模剂可防止在可固化组合物的气液界面中分布不均。