4-(1,3-benzodioxol-5-yl)-N-[5-(2-morpholin-4-yl-2-oxoethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide | 531550-67-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 4-(1,3-benzodioxol-5-yl)-N-[5-(2-morpholin-4-yl-2-oxoethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide
• CAS: 531550-67-1
• 化学式: C₂₁H₂₀N₄O₆S₂
• 分子量: 488.545
• InChiKey: QWYLIMWJQFLXOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  157
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
  申请人：——

  公开号：US20030130258A1

  公开（公告）日：2003-07-10

  The present invention relates to compounds with the formula (I) 1 and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-&bgr;-hydroxysteroid dehydrogenase type 1 enzyme.

  本发明涉及式 (I) 的化合物 1 以及包含这些化合物的药物组合物，还涉及这些化合物在医药中的用途和制备对人类 11-&bgr;- 羟基类固醇脱氢酶 1 型酶起作用的药物。
• INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
  申请人：BIOVITRUM AB

  公开号：EP1461327A1

  公开（公告）日：2004-09-29
• US7074788B2
  申请人：——

  公开号：US7074788B2

  公开（公告）日：2006-07-11
• [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE LA 11-BETA-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1
  申请人：BIOVITRUM AB

  公开号：WO2003044000A1

  公开（公告）日：2003-05-30

  The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-b-hydroxysteroid dehydrogenase type 1 enzyme.