(7aR)-3-((1S,2S,3S,4S)-1,2,3,4,5-pentahydroxypentyl)-5-thioxo-6-(o-tolyl)tetrahydro-3H,7H-imidazo[1,5-c]thiazol-7-one | 1300741-58-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (7aR)-3-((1S,2S,3S,4S)-1,2,3,4,5-pentahydroxypentyl)-5-thioxo-6-(o-tolyl)tetrahydro-3H,7H-imidazo[1,5-c]thiazol-7-one
• CAS: 1300741-58-5
• 化学式: C₁₇H₂₂N₂O₆S₂
• 分子量: 414.503
• InChiKey: AZAKTTVRFYOUPS-TYNRJXKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.19
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  124.7
• 氢给体数：
  5.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  、 邻甲苯异硫氰酸酯 在 吡啶 作用下， 反应 1.0h， 生成 (7aR)-3-((1S,2S,3S,4S)-1,2,3,4,5-pentahydroxypentyl)-5-thioxo-6-(o-tolyl)tetrahydro-3H,7H-imidazo[1,5-c]thiazol-7-one
  参考文献：
  名称：

  A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata

  摘要：

  An 80% acetone extract of Monarda punctata showed an inhibitory effect on lipase activity in isolated mouse plasma in vitro and carvacrol was obtained as the active constituent. It had an IC50 value of 4.07 mM in vitro and suppressed elevations in blood triacylglycerol levels in olive oil-loaded mice. Furthermore, from the whole plant, 22 compounds were isolated. Six monoterpene glycosides (3-8), a flavone glucuronide (9), and other known compounds were identified based on the results of spectroscopic analyses. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2010.08.009