N-(3,5-Diamino-6-chloropyrazine-2-carbonyl)-N'-[4-(4-bis(methanesulfonyl)aminophenyl)butyl]guanidine | 742101-90-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,5-Diamino-6-chloropyrazine-2-carbonyl)-N'-[4-(4-bis(methanesulfonyl)aminophenyl)butyl]guanidine
• 英文别名: 3,5-diamino-N-[N'-[4-[4-[bis(methylsulfonyl)amino]phenyl]butyl]carbamimidoyl]-6-chloropyrazine-2-carboxamide
• CAS: 742101-90-2
• 化学式: C₁₈H₂₅ClN₈O₅S₂
• 分子量: 533.032
• InChiKey: QRNRQCSYFGGXMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  234
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• Sodium channel blockers
  申请人：PARION SCIENCES, Inc.

  公开号：US20040162296A1

  公开（公告）日：2004-08-19

  The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

  本发明涉及钠通道阻滞剂。本发明还包括使用这些创新性钠通道阻滞剂的各种治疗方法。
• Hetero substitued sodium channel blockers
  申请人：Johnson R. Michael

  公开号：US20060142581A1

  公开（公告）日：2006-06-29

  The present invention relates to novel pyrazinoylguanidine compounds and methods of using the same.

  本发明涉及新型吡嗪酰基胍化合物及其使用方法。
• SODIUM CHANNEL BLOCKERS
  申请人：JOHNSON R. Michael

  公开号：US20080076782A1

  公开（公告）日：2008-03-27

  The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

  本发明涉及钠通道阻滞剂。本发明还包括使用这些创新的钠通道阻滞剂的各种治疗方法。
• HETERO SUBSTITUED SODIUM CHANNEL BLOCKERS
  申请人：Parion Sciences, Inc.

  公开号：EP1599096B1

  公开（公告）日：2008-12-24
• METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES
  申请人：Johnson Michael Ross

  公开号：US20090082287A1

  公开（公告）日：2009-03-26

  The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.