2-pyridin-3-yl-pyrrolidin-1-ylamine | 16543-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-pyridin-3-yl-pyrrolidin-1-ylamine
• 英文别名: 2-Pyridin-3-ylpyrrolidin-1-amine
• CAS: 16543-63-8
• 化学式: C₉H₁₃N₃
• 分子量: 163.222
• InChiKey: XMLJVWUSIAIJJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Selective reduction of tobacco-specific nitrosamines and related methods
  申请人：Massachusetts Institute of Technology

  公开号：US10383357B2

  公开（公告）日：2019-08-20

  Aspects of the present disclosure relate to electrochemical reduction of tobacco-specific nitrosamines (TSNAs). According to certain methods described herein, a tobacco composition containing one or more TSNAs and nicotine is contacted with a solvent to form a tobacco mixture. In some embodiments, the tobacco mixture is introduced into an electrochemical device comprising an anode and a cathode. The tobacco mixture may, in some cases, form at least part of an initial electrolyte mixture that is in physical contact with at least a portion of the anode and at least a portion of the cathode. In some instances, an electrical potential is applied between the anode and the cathode, thereby reducing one or more TSNAs in the initial electrolyte mixture and producing a reduced electrolyte mixture. In certain cases, application of the electrical potential between the anode and the cathode does not cause non-TSNA components of the tobacco mixture (e.g., nicotine) to undergo electrochemical reduction or any other chemical reaction.

  本公开的各个方面涉及烟草特异性亚硝胺（TSNAs）的电化学还原。根据本文所述的某些方法，将含有一种或多种 TSNA 和尼古丁的烟草组合物与溶剂接触以形成烟草混合物。在某些实施例中，将烟草混合物引入由阳极和阴极组成的电化学装置中。在某些情况下，烟草混合物可至少构成初始电解质混合物的一部分，该混合物与阳极的至少一部分和阴极的至少一部分发生物理接触。在某些情况下，在阳极和阴极之间施加电势，从而减少初始电解质混合物中的一种或多种 TSNA，并产生还原电解质混合物。在某些情况下，在阳极和阴极之间施加电势不会导致烟草混合物中的非 TSNA 成分（如尼古丁）发生电化学还原或任何其他化学反应。
• SELECTIVE REDUCTION OF TOBACCO-SPECIFIC NITROSAMINES AND RELATED METHODS
  申请人：Massachusetts Institute of Technology

  公开号：EP3454678A1

  公开（公告）日：2019-03-20
• [EN] SELECTIVE REDUCTION OF TOBACCO-SPECIFIC NITROSAMINES AND RELATED METHODS<br/>[FR] RÉDUCTION SÉLECTIVE DE NITROSAMINES SPÉCIFIQUES DU TABAC ET PROCÉDÉS ASSOCIÉS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2017197052A1

  公开（公告）日：2017-11-16

  Aspects of the present disclosure relate to electrochemical reduction of tobacco-specific nitrosamines (TSNAs). According to certain methods described herein, a tobacco composition containing one or more TSNAs and nicotine is contacted with a solvent to form a tobacco mixture. In some embodiments, the tobacco mixture is introduced into an electrochemical device comprising an anode and a cathode. The tobacco mixture may, in some cases, form at least part of an initial electrolyte mixture that is in physical contact with at least a portion of the anode and at least a portion of the cathode. In some instances, an electrical potential is applied between the anode and the cathode, thereby reducing one or more TSNAs in the initial electrolyte mixture and producing a reduced electrolyte mixture. In certain cases, application of the electrical potential between the anode and the cathode does not cause non-TSNA components of the tobacco mixture (e.g., nicotine) to undergo electrochemical reduction or any other chemical reaction.