2-(anthracen-9-yloxy)-N-((2S,3S)-1,3-dihydroxybutan-2-yl)acetamide | 1314801-57-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2-(anthracen-9-yloxy)-N-((2S,3S)-1,3-dihydroxybutan-2-yl)acetamide
• 英文别名: 2-(anthracen-9-yloxy)-N-(1,3-dihydroxybutan-2-yl)acetamide；2-anthracen-9-yloxy-N-[(2S,3S)-1,3-dihydroxybutan-2-yl]acetamide
• CAS: 1314801-57-4
• 化学式: C₂₀H₂₁NO₄
• 分子量: 339.391
• InChiKey: XOOIDWBLINEIKW-UGSOOPFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(anthracen-9-yloxy)-N-((2S,3S)-1,3-dihydroxybutan-2-yl)acetamide 在 吡啶 、 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 25.5h， 生成 3-(2-(anthracen-9-yloxy)acetamido)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)butan-2-yl 2-cyanoethyl diisopropylphosphoramidite
  参考文献：
  名称：

  Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

  摘要：

  含有蒽基的荧光 DNA 探针通过核苷酸连接体连接在一起，通过杂交感应试验，可以识别单个位点的所有四种 DNA 碱基以及表观遗传修饰 C/5-MeC。

  DOI：

  10.1039/c1cc11205h
• 作为产物：
  描述：

  O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 以49 %的产率得到2-(anthracen-9-yloxy)-N-((2S,3S)-1,3-dihydroxybutan-2-yl)acetamide
  参考文献：
  名称：

  Genetic probe for the detection of a single nucleotide polymorphism (SNP) or a single nucleotide modification of a target nucleic acid

  摘要：

  The present invention relates to a genetic probe comprising: a nanoparticle; an oligonucleotide probe anchored to the surface of the nanoparticle, comprising an oligonucleotide backbone with a tag incorporated therein via a linker group; and a reference probe anchored to the surface of the nanoparticle, wherein the reference probe comprises a marker; wherein either (a) the tag is an organic fluorescent tag and the marker is a transition metal-based fluorescent marker; or (b) the tag is a redox-active tag and the marker is a transition metal-based redox-active marker. The invention also relates to a composition or kit containing a probe of the invention.

  公开号：

  US12043865B2

文献信息

• Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes
  作者：Jean-Louis H. A. Duprey、Dario M. Bassani、Eva I. Hyde、Gediminas Jonusauskas、Christian Ludwig、Alison Rodger、Neil Spencer、Joseph S. Vyle、John Wilkie、Zheng-Yun Zhao、James H. R. Tucker

  DOI：10.1039/c8ob01710g

  日期：——

  The fluorescence sensing mechanism for identifying single base changes in target DNA strands has been established through detailed biophysical measurements.

  通过详细的生物物理测量，已经建立了用于识别目标DNA链中单个碱基变化的荧光感测机制。
• SENSOR
  申请人：The University of Birmingham

  公开号：US20200332349A1

  公开（公告）日：2020-10-22

  The present invention relates to a genetic probe for the detection of a single nucleotide polymorphism (SNP) or a single nucleotide modification of a target nucleic acid, the genetic probe comprising: —a nanoparticle; —an oligonucleotide probe anchored to the surface of the nanoparticle, comprising an oligonucleotide backbone with a tag incorporated therein via a linker group; and —a reference probe anchored to the surface of the nanoparticle, wherein the reference probe comprises a marker; wherein either (a) the tag is an organic fluorescent tag and the marker is a transition metal-based fluorescent marker; or (b) the tag is a redox-active tag and the marker is a transition metal-based redox-active marker. The invention also relates to a composition or kit containing a probe of the invention, or to the use of a probe of the invention. The invention also relates to a method of determining the percentage of single nucleotide polymorphisms (SNPs) or single nucleotide modifications of a target nucleic acid in a pool of the target nucleic acid, or to a method of determining the status of a condition associated with a known SNP in a subject