(2-methyl-4,6-diphenylpyridin-3-ylcarbonyl)(morpholin-4-yl)ketone | 1398101-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (2-methyl-4,6-diphenylpyridin-3-ylcarbonyl)(morpholin-4-yl)ketone
• 英文别名: (2-methyl-4,6-diphenylpyridin-3-yl)(morpholino)methanone；(2-Methyl-4,6-diphenylpyridin-3-yl)-morpholin-4-ylmethanone
• CAS: 1398101-66-0
• 化学式: C₂₃H₂₂N₂O₂
• 分子量: 358.44
• InChiKey: LWANQVKXOIOHQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-乙酰丙酮吗啉 、 苯亚甲基苯乙酮 在 ammonium cerium (IV) nitrate 、 ammonium acetate 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以80%的产率得到(2-methyl-4,6-diphenylpyridin-3-ylcarbonyl)(morpholin-4-yl)ketone
  参考文献：
  名称：

  One-Pot Access to a Library of Structurally Diverse Nicotinamide Derivatives via a Three-Component Formal Aza [3 + 3] Cycloaddition

  摘要：

  The three-component formal [3 + 3] aza-annulation between chalcones, beta-ketoamides, and ammonium acetate in the presence of CAN as a Lewis acid affords good to excellent yields of highly substituted nicotinamides or their fused derivatives. This transformation leads to the formation of one C-C and two C-N bonds in a single synthetic operation and involves up to five individual steps.

  DOI：

  10.1021/co300081k

文献信息

• Synthesis of polysubstituted pyridines from oxime acetates using NH₄I as a dual-function promoter
  作者：Yujia Xia、Jinhui Cai、Huawen Huang、Guo-Jun Deng

  DOI：10.1039/c7ob02471a

  日期：——

  Pyridine formation with oxime acetates as the building blocks under metal-free conditions is described. Ammonium iodide has proved to be a highly efficient promoter for oxime N–O bond reduction and subsequent condensation reactions, whereby it played a dual-function role in the transformation. While the three-component reaction of oxime acetates, benzaldehydes, and 1,3-dicarbonyls proceeded well with

  描述了在无金属条件下以肟肟作为结构单元生成吡啶的方法。碘化铵已被证明是肟氮键还原和随后的缩合反应的高效促进剂，因此在转化中起着双重作用。尽管在化学计量的碘化铵的帮助下，肟肟，苯甲醛和1,3-二羰基肟的三组分反应进展顺利，但通过使用催化引发剂，肟和丙烯醛的缩合反应可提供取代的吡啶。通过该方案，以中等至优异的产率产生了对许多官能团具有耐受性的取代吡啶产物。