2-氟-4-甲基-5-硝基苯甲醛 | 1804054-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氟-4-甲基-5-硝基苯甲醛
• 英文名称: 2-Fluoro-4-methyl-5-nitrobenzaldehyde
• CAS: 1804054-69-0
• 化学式: C8H6FNO3
• 分子量: 183.14
• InChiKey: FRDWVXUIJCCEQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险类别：
  6.1
• 危险性防范说明：
  P261,P264,P270,P271,P280,P302+P352,P304+P340,P310,P330,P361,P403+P233,P405,P501
• 危险品运输编号：
  2811
• 危险性描述：
  H301,H311,H331
• 包装等级：
  III

文献信息

• Indazole Compounds as IRAK4 Inhibitors
  申请人：AURIGENE DISCOVERY TECHNOLOGIES LIMITED

  公开号：US20160326151A1

  公开（公告）日：2016-11-10

  The present invention provides indazole compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors, wherein Z 1 , Z 2 , R 1 , R 2 , R 3 , ‘m’ and ‘n’ have the meanings given in the specification, and pharmaceutically acceptable salts or stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical compositions comprising at least one of the compounds of the compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient.

  本发明提供了式（I）的吲唑化合物，作为激酶抑制剂在治疗上具有疗效，特别是IRAK4抑制剂，其中Z1、Z2、R1、R2、R3、'm'和'n'在规范中给出了含义，并且其药学上可接受的盐或立体异构体在治疗和预防疾病或疾病中有用，特别是它们在由激酶酶介导的疾病或疾病中的使用，特别是IRAK4酶。本发明还提供了包括至少一种式（I）化合物的药物组合物，以及药学上可接受的载体、稀释剂或赋形剂。
• INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS
  申请人：AURIGENE DISCOVERY TECHNOLOGIES LIMITED

  公开号：US20180201609A1

  公开（公告）日：2018-07-19

  The present invention provides indazole and aza indazole compounds of formula (I) or (II) and pharmaceutically acceptable salts thereof, and their use to inhibit IRAK-4 and/or for the treatment of diseases or disorders induced by IRAK-4.