2,8-di-pyridin-4-yl-pyrido[1,2-a]pyrimidin-4-one | 1202398-74-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,8-di-pyridin-4-yl-pyrido[1,2-a]pyrimidin-4-one
• 英文别名: 2,8-Dipyridin-4-ylpyrido[1,2-a]pyrimidin-4-one
• CAS: 1202398-74-0
• 化学式: C₁₈H₁₂N₄O
• 分子量: 300.319
• InChiKey: DHFHNFBTDSYXRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Substituted pyrimidone derivatives
  申请人：Sanofi-Aventis

  公开号：EP2138493A1

  公开（公告）日：2009-12-30

  Pyrimidone derivatives of formula (I) wherein: R1 represents a 4-pyridine ring; R2 represents a hydrogen atom; R3 represents a hydrogen atom; R4 represents : a hydrogen atom; a phenyl ring, this ring being optionally substituted by 1 to 4 substituents selected from a C1-6 alkyl group, a halogen atom, a C1-2 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group, a C1-2 halogenated alkoxy group, R5 represents a hydrogen atom, a C1-6 alkyl group, a 4-pyridine group, a phenyl group, these groups being optionally substituted, R6 represents a hydrogen atom, a C1-6 alkyl group, a benzyloxy group, a phenyl C1-6 alkyl group, these groups being optionally substituted, in form of a free base or of an addition salt with an acid. Use in therapeutic.

  公式（I）中的吡啶酮衍生物，其中：R1代表4-吡啶环；R2代表氢原子；R3代表氢原子；R4代表：氢原子；苯环，该环可选地被1至4个取自C1-6烷基，卤素原子，C1-2卤代烷基，羟基，C1-6烷氧基，C1-2卤代烷氧基的取代基所取代；R5代表氢原子，C1-6烷基，4-吡啶基，苯基，这些基可选地被取代；R6代表氢原子，C1-6烷基，苄氧基，苯基C1-6烷基，这些基可选地被取代，以自由碱或酸加成盐的形式使用于治疗。
• SUBSTITUTED PYRIMIDONE DERIVATIVES
  申请人：LOCHEAD Alistair

  公开号：US20110144133A1

  公开（公告）日：2011-06-16

  Pyrimidone derivatives of formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I) and their use in therapeutics.

  公式（I）的吡啶酮衍生物，其中R1、R2、R3、R4、R5和R6如所述。还公开了制备公式（I）化合物的方法以及它们在治疗中的应用。
• JP2011525906A
  申请人：——

  公开号：JP2011525906A

  公开（公告）日：2011-09-29
• US9073915B2
  申请人：——

  公开号：US9073915B2

  公开（公告）日：2015-07-07
• [EN] SUBSTITUTED PYRIMIDONE DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRIMIDONE SUBSTITUÉS
  申请人：MITSUBISHI TANABE PHARMA CORP

  公开号：WO2009156861A2

  公开（公告）日：2009-12-30

  Pyrimidone derivatives of formula (I) wherein: R1 represents a 4-pyridine ring; R2 represents a hydrogen atom; R3 represents a hydrogen atom; R4 represents : a hydrogen atom; a phenyl ring, this ring being optionally substituted by 1 to 4 substituents selected from a C1-6 alkyl group, a halogen atom, a C1-2 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group, a C1-2 halogenated alkoxy group, R5 represents a hydrogen atom, a C1-6 alkyl group, a 4-pyridine group, a phenyl group, these groups being optionally substituted, R6 represents a hydrogen atom, a C1-6 alkyl group, a benzyloxy group, a phenyl C1-6 alkyl group, these groups being optionally substituted, in form of a free base or of an addition salt with an acid. Use in therapeutic.