2-{4-[4-(2-Hydroxy-ethyl)-phenylsulfanyl]-phenyl}-ethanol | 6013-53-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-{4-[4-(2-Hydroxy-ethyl)-phenylsulfanyl]-phenyl}-ethanol
• 英文别名: 2-[4-[4-(2-Hydroxyethyl)phenyl]sulfanylphenyl]ethanol
• CAS: 6013-53-2
• 化学式: C₁₆H₁₈O₂S
• 分子量: 274.384
• InChiKey: JFIGGLCXIFKKJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 4-alkyl-1, 4-dihydropyridines with PAF-antagonist activity
  申请人：ALTER, S.A.

  公开号：EP0325187A1

  公开（公告）日：1989-07-26

  4-alkyl-1,4-dihyropyridines, with PAF-antagonist activity, of formula (I) wherein R is saturated C₁-C₄, R′ is saturated C₁-C₆ alkyl which may be interrupted by an oxygen atom, or 2-tetrahydrofurfuryl and R² is saturated C₁-C₄ or phenyl, the compound wherein R is methyl, R′ is ethyl and R² is phenyl remain excluded, are described. The compounds (I) are prepared by: (a) reaction of (II) with (III); (b) reaction of (IV) with (V); (c) reaction of (VI) with (III) and with (VII); (d) reaction of (VIII) with (V) and with (VII); or (e) reaction of (VIII) with (VI) and with (VII) in the presence of ammonia. The compounds (I) are useful due to their antagonist activity of the platelet activating factor.

  具有 PAF-拮抗剂活性的式 (I) 的 4-烷基-1,4-二氢吡啶类化合物 其中 R 是饱和 C₁-C₄，R′是饱和 C₁-C₆烷基，可被氧原子打断、或 2-四氢糠基且 R² 为饱和 C₁-C₄ 或苯基的化合物，不包括 R 为甲基、R′ 为乙基且 R² 为苯基的化合物。 化合物 (I) 的制备方法如下(a) (II) 与 (III) 反应；(b) (IV) 与 (V) 反应；(c) (VI) 与 (III) 和 (VII) 反应；(d) (VIII) 与 (V) 和 (VII) 反应；或 (e) (VIII) 与 (VI) 和 (VII) 在氨存在下反应。化合物(I)具有拮抗血小板活化因子的活性，因此非常有用。
• DUAL-USE MICRO ENCAPSULATION COMPOSITION FOR HYDROCARBONS AND DETOXIFICATION OF HIGHLY HAZARDOUS CHEMICALS AND SUBSTANCES
  申请人：Burns Lyle D.

  公开号：US20090245939A1

  公开（公告）日：2009-10-01

  A two-component, water based micro encapsulation composition and method for the cleanup of hydrocarbon spills or contaminates on various surfaces and media. The two-part formulation includes a first solution including water in a predetermined ratio of a water soluble alkaline silicate solution having at least one alkali metal and a predetermined ratio of at least one water soluble surfactant; and a second solution including water, a predetermined ratio of water soluble acid, a predetermined ratio of water dispersible polymer, a predetermined ratio of water soluble hydrotrope, and a predetermined ratio of at least one water soluble flocculating agent. A method of using the two-part formulation includes preparing the two-part formulation, allowing the first solution to contact the hydrocarbon or chemical contaminate; allowing the second solution to contact the first solution and contaminate to form a homogeneous mixture; and removing the homogeneous mixture.
• US4122258A
  申请人：——

  公开号：US4122258A

  公开（公告）日：1978-10-24