2',3'-Dimethylbiphenyl-3-carboxylic acid | 1215206-78-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2',3'-Dimethylbiphenyl-3-carboxylic acid
• 英文别名: 3-(2,3-dimethylphenyl)benzoic acid
• CAS: 1215206-78-2
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.27
• InChiKey: NZCHUDYYICLURF-UHFFFAOYSA-N

物化性质

• 沸点：
  390.4±21.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 3-(4-BENZYLOXYPHENYL)PROPANOIC ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDE 3-(4-BENZYLOXYPHENYL) PROPANOIQUE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2005063729A1

  公开（公告）日：2005-07-14

  The present invention provides a novel compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof having a superior GPR40 receptor function modulating action, which can be used as an insulin secretagogue, an agent for the prophylaxis or treatment of diabetes and the like. They unexpectedly show superior GPR40 receptor agonist activity, and also show superior properties as a pharmaceutical product, such as stability and the like. Thus, they can be safe and useful pharmaceutical agents for the prophylaxis or treatment of GPR40 receptor related diseases in mammals.

  本发明提供了一种由公式(I)表示的新的化合物，其中每个符号如说明书中所定义，以及其盐和前药，具有优越的GPR40受体功能调节作用，可用作胰岛素分泌剂，用于预防或治疗糖尿病等的药剂。它们出人意料地显示出优越的GPR40受体激动剂活性，并且还显示出作为药物产品的优越性质，如稳定性等。因此，它们可以成为预防或治疗哺乳动物中与GPR40受体相关疾病的既安全又有用的药物。
• Method For Producing Aminoalcohol Derivative Having Biphenyl Group
  申请人：Kasai Kiyoshi

  公开号：US20090030218A1

  公开（公告）日：2009-01-29

  The present invention provides an industrial method for preparing aminoalcohol derivatives (I) having a biphenyl group, biphenyloxyacetaldehyde derivatives which are used therefore, preparing methods thereof, and intermediates used for the preparing method. The present invention also provides a preparing method including processes for preparing a 3-substituted biphenylcarboxylic acid derivative represented by the following general formula: by allowing a 3-fluorobiphenylcarboxylic acid derivative prepared from a 3-fluorobiphenylcarbonitrile derivative which can be prepared by allowing a 4-halophenol derivative to react with a 2-fluorobenzonitrile derivative which is substituted by a leaving group at 4-position to react with an organometallic reagent.

  本发明提供了一种工业方法，用于制备具有二苯基基团的氨基醇衍生物（I），用于其的二苯氧乙醛衍生物，其制备方法以及用于制备方法的中间体。本发明还提供了一种制备方法，包括通过以下一般式所代表的过程制备3-取代的二苯基羧酸衍生物： 通过让从3-氟代二苯基碳腈衍生物制备的3-氟代二苯基羧酸衍生物与在4-位置上被离去基取代的2-氟苯甲腈衍生物反应，然后与有机金属试剂反应。
• EP1611089A2
  申请人：——

  公开号：EP1611089A2

  公开（公告）日：2006-01-04
• 3-(4-BENZYLOXYPHENYL)PROPANOIC ACID DERIVATIVES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1697339A1

  公开（公告）日：2006-09-06
• POLYMORPHIC CRYSTAL OF 4'-{2-[ (1S, 2R) - 2- HYDROXY -2- (4-HYDROXYPHENYL) -1- METHYLETHYLAMINO] ETHOXY} - 3 - ISOPROPYL-3', 5' -DIMETHYLBIPHENYL - 4 - CARBOXYLIC ACID HYDROCHLORIDE
  申请人：KASAI Kiyoshi

  公开号：US20080076826A1

  公开（公告）日：2008-03-27

  Crystals of a salt of 4′-2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3-isopropyl-3′, 5′-dimethylbiphenyl-4-carboxylic acid. The α type, β type and γ type crystals produced by treating hydrochloride of 4′-2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl-amino]ethoxy}-3-isopropyl-3′,5′-dimethylbiphenyl-4-carboxylic acid with specified solvents, which can be discriminated by the characteristic diffraction peaks of powder X-ray diffractometry and the like.