5'-fluoro-2'-methoxybiphenyl-3-carboxylic acid | 376592-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5'-fluoro-2'-methoxybiphenyl-3-carboxylic acid
• 英文别名: 3-(5-Fluoro-2-methoxyphenyl)benzoic acid
• CAS: 376592-43-7
• 化学式: C₁₄H₁₁FO₃
• 分子量: 246.238
• InChiKey: XQQAQLGWHVTMBZ-UHFFFAOYSA-N

物化性质

• 沸点：
  398.1±32.0 °C(Predicted)
• 密度：
  1.259±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-氟-2-甲氧基苯硼酸 、 4-羧基苯硼酸 、 间溴苯甲酸 、 生成 5'-fluoro-2'-methoxybiphenyl-3-carboxylic acid
  参考文献：
  名称：

  THROMBOPOIETIN MIMETICS

  摘要：

  发明了非肽类TPO类似物。同时发明了用于制备目前发明化合物的新型工艺和中间体。另外，发明了一种治疗血小板减少症的方法，包括对需要治疗的哺乳动物，包括人类，给予所选的羟基-1-偶氮苯衍生物的有效剂量。

  公开号：

  US20070129338A1

文献信息

• Thrombopoietin mimetics
  申请人：——

  公开号：US20040019190A1

  公开（公告）日：2004-01-29

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy- 1 -azobenzene derivative.

  发明了非肽类TPO类似物。还发明了用于制备目前发明的化合物的新工艺和中间体。还发明了一种治疗血小板减少症的方法，包括给予需要的哺乳动物，包括人类，有效量的选择性羟基-1-偶氮苯衍生物。
• EP1294378A4
  申请人：——

  公开号：EP1294378A4

  公开（公告）日：2004-01-28
• [EN] THROMBOPOIETIN MIMETICS<br/>[FR] MIMIQUES DE THROMBOPOIETINE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2001089457A2

  公开（公告）日：2001-11-29

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
• THROMBOPOIETIN MIMETICS
  申请人：Duffy Kevin J.

  公开号：US20130078213A1

  公开（公告）日：2013-03-28

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

  本发明涉及非肽类TPO类似物的发明。本发明还涉及用于制备目前发明的化合物的新型过程和中间体。本发明还涉及一种治疗血小板减少症的方法，包括在需要的哺乳动物（包括人类）中给予所选的羟基-1-偶氮苯衍生物的有效量。