2-oxo-2-[(2,3,4-trichlorophenyl)amino]ethyl dibenzyldithiocarbamate | 864661-38-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-oxo-2-[(2,3,4-trichlorophenyl)amino]ethyl dibenzyldithiocarbamate
• 英文别名: 2-[(2,3,4-Trichlorophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate；[2-oxo-2-(2,3,4-trichloroanilino)ethyl] N,N-dibenzylcarbamodithioate
• CAS: 864661-38-1
• 化学式: C₂₃H₁₉Cl₃N₂OS₂
• 分子量: 509.908
• InChiKey: PHGPMCRQGMGGQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  89.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Carbamates as HIV anti-viral agents
  申请人：Olson W. Matthew

  公开号：US20050203176A1

  公开（公告）日：2005-09-15

  The present invention relates to carbamate derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the carbamate derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the carbamate derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

  本发明涉及具有RNase H、聚合酶和/或HIV反转录酶调节和特别是抑制活性的氨基甲酸酯衍生物。该发明包括氨基甲酸酯衍生物、含有该衍生物的组合物、合成该衍生物的方法、筛选该衍生物的方法以及使用氨基甲酸酯衍生物进行治疗的方法，包括治疗HIV、艾滋病和逆转录病毒相关癌症的方法。
• [EN] CARBAMATES AS HIV ANTI-VIRAL AGENTS<br/>[FR] CARBAMATES UTILISES EN TANT QU'AGENTS ANTI-VIH
  申请人：WYETH CORP

  公开号：WO2005090299A2

  公开（公告）日：2005-09-29

  The present invention relates to carbamate derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the carbamate derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the carbamate derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.