2,3-Dcpe hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-Dcpe hydrochloride
• 英文别名: 2-[3-(2,3-dichlorophenoxy)propylamino]ethanol;hydrochloride
• 化学式: C11H16Cl3NO2
• 分子量: 300.6
• InChiKey: GFCJFYSIPRIHKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.77
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  41.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Use of Bcl inhibitors For The Prevention Of Fibroproliferative Reclosure Of Dilated Blood Vessels And Other Iatrogenic Fibroproliferative Disorders
  申请人：McCaffrey Timothy A.

  公开号：US20080057098A1

  公开（公告）日：2008-03-06

  The present invention relates to new use of inhibitors of bcl-2/bcl-XI family of anti-apoptotic compounds for the treatment of post-angioplasty restenosis and in-stent restenosis. Small molecules of Bcl inhibitors are incorporated into a stent, typically by a fine polymeric coating over the metal, which would be placed during angioplasty of occluded blood vessels, to act on fibroproliferative in-growth. Hollow organs such as urethras, Fallopian tubes and vascular access grafts could be treated in a similar manner to prevent their closure due to fibrosis. Other iatrogenic fibrosis such as adhesions after surgery could also be blocked by this therapy.
• Use of Bcl Inhibitors for the Treatment of Scarring Caused By Cutaneous Wounds, Burns and Abrasions
  申请人：McCaffrey Tim

  公开号：US20110091552A1

  公开（公告）日：2011-04-21

  The present invention relates to use of Bcl inhibitors for the prevention of fibroproliferation resulting in the growth of visible or disfiguring scar tissue on human skin, including without limitation keloids and hypertrophic scars. In particular, the present invention relates to the new use of small molecule inhibitors of the Bcl-2/Bcl-XL family of anti-apoptotic proteins for the treatment of cutaneous wounds, burns and abrasions during the healing phase.
• US7857804B2
  申请人：——

  公开号：US7857804B2

  公开（公告）日：2010-12-28