3-Aethyl-4,4-dimethyl-azetidinon-(2) | 16933-96-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 3-Aethyl-4,4-dimethyl-azetidinon-(2)
• 英文别名: 3-Ethyl-4,4-dimethylazetidin-2-one
• CAS: 16933-96-3
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: HOGZYPVAGUNSTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-Aethyl-4,4-dimethyl-azetidinon-(2) 在 盐酸 作用下， 生成 2-ethyl-3-amino-3-methyl-butyric acid
  参考文献：
  名称：

  The reaction of chlorosulfonyl isocyanates with allenes and olefins

  摘要：

  DOI：

  10.1021/jo01272a005

文献信息

• Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same
  申请人：Stahl S. Shannon

  公开号：US20070087404A1

  公开（公告）日：2007-04-19

  Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS) 2 ), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
• POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME
  申请人：Stahl Shannon S.

  公开号：US20100222250A1

  公开（公告）日：2010-09-02

  Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS) 2 ), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
• NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME
  申请人：Gellman Samuel H.

  公开号：US20130004453A1

  公开（公告）日：2013-01-03

  Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins Band C (SP-B and SP-C), two helical and amphiphilic proteins that are clitical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restlicted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-R mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, arc prepared by ling-opening polymelization of 13-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B.
• NYLON-3 POLYMERS ACTIVE AGAINST CLOSTRIDIUM DIFFICILE
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20170000818A1

  公开（公告）日：2017-01-05

  A method and corresponding composition to inhibit outgrowth of C. difficile spores and/or to inhibit growth of C. difficile vegetative cells in a mammal in which an amount of a nylon-3 polymer or nylon-3 copolymer or a pharmaceutically suitable salt thereof is administered to the subject.
• US7951912B2
  申请人：——

  公开号：US7951912B2

  公开（公告）日：2011-05-31