1-(3-Pyridyl-acetyl)-pyrrolidin | 91718-04-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3-Pyridyl-acetyl)-pyrrolidin
• 英文别名: 1-(pyridin-3-yl-acetyl)-pyrrolidine；2-(Pyridin-3-yl)-1-(pyrrolidin-1-yl)ethan-1-one；2-pyridin-3-yl-1-pyrrolidin-1-ylethanone
• CAS: 91718-04-6
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: ZEHUZQONHCEKII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• SMALL MOLECULE INHIBITORS OF DYRK1/CLK AND USES THEREOF
  申请人：Arizona Board of Regents on behalf of the University of Arizona

  公开号：EP3856186A1

  公开（公告）日：2021-08-04
• [EN] SMALL MOLECULE INHIBITORS OF DYRK1/CLK AND USES THEREOF<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE DYRK1/CLK ET LEURS UTILISATIONS
  申请人：UNIV ARIZONA

  公开号：WO2020069418A1

  公开（公告）日：2020-04-02

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a 6,5-heterocyclic structure (e.g., compounds having a imidazopyridine, imidazopyrimidine, imidazopyrazine, imidazopyridazine, imidazotriazine, benzoimidazole, benzotriazole, benzoisoxazole, purine, indazole, triazolotriazine, triazolopyridazine, triazolopyrimidine, triazolopyrazine, triazolotetrazine, triazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolopyridazine, pyrazolotriazine, pyrazolopyridine, isoxazolopyrazine, isoxazolopyrimidine, isoxazolopyrdiazine, isoxazolotriazine, or isoxalopyridine structure) which function as inhibitors of DYRK1A, DYRK1B, and Clk-1, and their use as therapeutics for the treatment of Alzheimer's disease, Down syndrome, diabetes, glioblastoma, autoimmune diseases, cancer (e.g., glioblastoma, prostate cancer), inflammatory disorders (e.g., airway inflammation), and other diseases.