4-(Methoxymethyl)benzene-1-sulfonyl chloride | 605655-15-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(Methoxymethyl)benzene-1-sulfonyl chloride
• 英文别名: 4-(methoxymethyl)benzenesulfonyl chloride
• CAS: 605655-15-0
• 化学式: C₈H₉ClO₃S
• mdl: MFCD18324257
• 分子量: 220.67
• InChiKey: WKWGSOIGLWSEPZ-UHFFFAOYSA-N

物化性质

• 沸点：
  289.7±23.0 °C(Predicted)
• 密度：
  1.335±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] CARBAMATES AS HIV PROTEASE INHIBITORS<br/>[FR] CARBAMATES INHIBITEURS DE PROTEASE DU VIH
  申请人：UNIV ILLINOIS

  公开号：WO2003078438A1

  公开（公告）日：2003-09-25

  Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as thereapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed.

  本发明揭示了用于抑制HIV蛋白酶的化合物。本发明还揭示了制备这些化合物的方法以及它们作为治疗剂的用途，例如用于治疗野生型HIV和多药耐药株的HIV。
• HIV protease inhibitors
  申请人：——

  公开号：US20040039016A1

  公开（公告）日：2004-02-26

  Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed.

  本文披露了用于抑制HIV蛋白酶的化合物。同时，还披露了制备这些化合物的方法，以及它们作为治疗剂的用途，例如用于治疗野生型HIV和多药耐药株的HIV。
• HETEROCYCLIC COMPOUNDS AND METHODS OF USE
  申请人：Bach Thomas Andrew

  公开号：US20070135502A1

  公开（公告）日：2007-06-14

  Compounds of the formula provide pharmacological agents which are potent agonists of Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis and Crohn's disease. The compounds of the present invention are particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X. Preferred are the compounds of the invention which are dual agonists of PPARα and PPARγ receptors.

  该公式化合物提供了对过氧化物酶体增殖物激活受体（PPARs）具有强效激动剂作用的药理制剂。因此，本发明的化合物对于治疗哺乳动物PPAR受体活性介导的疾病是有用的。这些疾病包括：血脂异常、高血脂、高胆固醇血症、动脉粥样硬化、高三酰甘油血症、心力衰竭、心肌梗塞、血管疾病、心血管疾病、高血压、肥胖、炎症、关节炎、癌症、阿尔茨海默病、皮肤疾病、呼吸道疾病、眼科疾病、炎症性肠病、溃疡性结肠炎和克罗恩病。本发明的化合物在哺乳动物中作为降糖剂特别有用，用于治疗和预防出现受损的葡萄糖耐受性、高血糖和胰岛素抵抗的疾病，例如1型和2型糖尿病和X综合症。本发明的化合物中，对于同时激活PPARα和PPARγ受体的双重激动剂，更为优选。
• CARBAMATES AS HIV PROTEASE INHIBITORS
  申请人：BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：EP1485387A1

  公开（公告）日：2004-12-15
• US7157489B2
  申请人：——

  公开号：US7157489B2

  公开（公告）日：2007-01-02