2-{Acetyl-[2-(2-iodo-phenyl)-ethyl]-amino}-acrylic acid methyl ester | 171734-15-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{Acetyl-[2-(2-iodo-phenyl)-ethyl]-amino}-acrylic acid methyl ester
• CAS: 171734-15-9
• 化学式: C₁₄H₁₆INO₃
• 分子量: 373.19
• InChiKey: RGDDRWBWSKRNSV-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-{Acetyl-[2-(2-iodo-phenyl)-ethyl]-amino}-acrylic acid methyl ester 在 palladium diacetate 、 3 A molecular sieve 、 四丁基氯化铵 、 碳酸氢钠 作用下， 以 乙腈 为溶剂， 反应 16.5h， 以54%的产率得到3-Acetyl-4,5-dihydro-3H-benzo[d]azepine-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis of 7-, 8- and 9-membered rings via endo Heck cyclisations of amino acid derived substrates

  摘要：

  Aryl iodides tethered to dehydroalanine units by two to four methylene groups undergo intramolecular Heck reactions under anhydrous Jeffery conditions to give 7-, 8- and 9-membered rings by the endo-mode of cyclisation; under harsher; conditions, a palladium intermediate formed by the exo-mode of cyclisation is expressed as reduced products.

  DOI：

  10.1039/c39950001743
• 作为产物：
  描述：

  3-Acetoxy-2-{acetyl-[2-(2-iodo-phenyl)-ethyl]-amino}-propionic acid methyl ester 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 生成 2-{Acetyl-[2-(2-iodo-phenyl)-ethyl]-amino}-acrylic acid methyl ester
  参考文献：
  名称：

  Synthesis of 7-, 8- and 9-membered rings via endo Heck cyclisations of amino acid derived substrates

  摘要：

  Aryl iodides tethered to dehydroalanine units by two to four methylene groups undergo intramolecular Heck reactions under anhydrous Jeffery conditions to give 7-, 8- and 9-membered rings by the endo-mode of cyclisation; under harsher; conditions, a palladium intermediate formed by the exo-mode of cyclisation is expressed as reduced products.

  DOI：

  10.1039/c39950001743