| 162825-90-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• CAS: 162825-90-3
• 化学式: C₇₃H₇₉ClN₅O₂₁P
• 分子量: 1428.88
• InChiKey: QPUFHSJEHRFEAT-XWTSJKSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.45
• 重原子数：
  101.0
• 可旋转键数：
  29.0
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  296.87
• 氢给体数：
  3.0
• 氢受体数：
  23.0

反应信息

• 作为反应物：
  描述：

  在 四甲基胍 、 4-硝基苯甲醛肟 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  RNA Modified Uridines VII: Chemical Synthesis and Initial Analysis of tRNA D-Loop Oligomers with Tandem Modified Uridines

  摘要：

  The first chemical synthesis of oligoribonucleotides with adjacent and significantly different modified uridines, the hydrophobic dihydrouridine, D, and the hydrophilic 3-[3-(S)-amino-3-carboxypropyl]-uridine, (acp)U-3, is reported. The trimers Dp-acp(3)UpA, Up-acp(3)UpA, DpUpA and UpUpA, and the dimer Dp-acp(3)U were synthesized and initial structural analysis performed. The synthesis included a combination of protecting groups that is generally applicable to oligonucleotide syntheses in combination with various 2'OH protecting groups. The protecting groups did not cause racemization of the amino acid residue of (acp)3U during deprotection. The assignment of all H-1 NMR resonances of modified nucleoside-containing oligoribonucleotides includes heteronuclear one and two dimensional NMR.

  DOI：

  10.1080/15257779508014659
• 作为产物：
  描述：

  (S)-2-Benzyloxycarbonylamino-4-{3-[(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyric acid benzyl ester 、 在 1-(mesitylen-2-sulfonyl)-1H-1,2,4-triazole 作用下， 以 吡啶 为溶剂， 反应 144.0h， 以66%的产率得到
  参考文献：
  名称：

  RNA Modified Uridines VII: Chemical Synthesis and Initial Analysis of tRNA D-Loop Oligomers with Tandem Modified Uridines

  摘要：

  The first chemical synthesis of oligoribonucleotides with adjacent and significantly different modified uridines, the hydrophobic dihydrouridine, D, and the hydrophilic 3-[3-(S)-amino-3-carboxypropyl]-uridine, (acp)U-3, is reported. The trimers Dp-acp(3)UpA, Up-acp(3)UpA, DpUpA and UpUpA, and the dimer Dp-acp(3)U were synthesized and initial structural analysis performed. The synthesis included a combination of protecting groups that is generally applicable to oligonucleotide syntheses in combination with various 2'OH protecting groups. The protecting groups did not cause racemization of the amino acid residue of (acp)3U during deprotection. The assignment of all H-1 NMR resonances of modified nucleoside-containing oligoribonucleotides includes heteronuclear one and two dimensional NMR.

  DOI：

  10.1080/15257779508014659