(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(4-((3-(methylsulfonyl)phenyl)sulfonyl)piperazin-1-yl)methanone | 1355051-60-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(4-((3-(methylsulfonyl)phenyl)sulfonyl)piperazin-1-yl)methanone
• 英文别名: [6-[4-(4-fluorophenoxy)phenyl]pyridin-2-yl]-[4-(3-methylsulfonylphenyl)sulfonylpiperazin-1-yl]methanone
• CAS: 1355051-60-3
• 化学式: C₂₉H₂₆FN₃O₆S₂
• 分子量: 595.672
• InChiKey: YKEHPVZQEQULHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  (6-(4-(4-Fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone 、 3-(甲基磺酰基)苯-1-磺酰氯 、 N,N-二异丙基乙胺 以 二氯甲烷 为溶剂， 以to give compound 8 in 84% yield (LC/MS (m/z+H)=596; 1H NMR (CDCl3) δ ppm: 6.8-8.5 (m, 15H); 4.0 (m, 4H); 3.3 (m, 4H); 3.2 (s, 3H))的产率得到(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(4-((3-(methylsulfonyl)phenyl)sulfonyl)piperazin-1-yl)methanone
  参考文献：
  名称：

  PYRIDINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS

  摘要：

  该发明涉及式(I)的取代吡啶化合物，或其药学上可接受的盐、前药或溶剂，其中A1、X、A2、R1a、R1b、R1c、G和z如规范中所述。该发明还涉及使用式(I)的化合物治疗对钠通道阻滞有反应的疾病。本发明的化合物特别适用于治疗疼痛。

  公开号：

  US20150344465A1

文献信息

• [EN] PYRIDINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS<br/>[FR] COMPOSÉS PYRIDINES COMME BLOQUEURS DES CANAUX SODIQUES
  申请人：PURDUE PHARMA LP

  公开号：WO2012007836A1

  公开（公告）日：2012-01-19

  The invention relates to substituted pyridine compounds of Formula I: (I) or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein A1, X, A2, R1a, R1b, R1c, G, and z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

  该发明涉及公式I的取代吡啶化合物：(I)或其药学上可接受的盐、前药或溶剂化合物，其中A1、X、A2、R1a、R1b、R1c、G和z的定义如规范中所述。该发明还涉及利用公式I的化合物治疗对钠通道阻滞有响应的疾病。本发明的化合物特别适用于治疗疼痛。
• Pyridine Compounds as Sodium Channel Blockers
  申请人：Kyle Donald J.

  公开号：US20130345211A1

  公开（公告）日：2013-12-26

  The invention relates to substituted pyridine compounds of Formula I: (I) or a pharmaceutically acceptable salt, prodrug, or solvate thereof wherein A 1 , X, A 2 , R 1a , R 1b , R 1c , G, and z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及式I的取代吡啶化合物：（I）或其药学上可接受的盐，前药或溶剂，其中A1，X，A2，R1a，R1b，R1c，G和z如规范所述。本发明还涉及使用式I的化合物来治疗对钠通道阻滞有反应的疾病。本发明的化合物特别适用于治疗疼痛。
• Pyridine compounds as sodium channel blockers
  申请人：Kyle Donald J.

  公开号：US09120752B2

  公开（公告）日：2015-09-01

  The invention relates to substituted pyridine compounds of Formula I: (I) or a pharmaceutically acceptable salt, prodrug, or solvate thereof wherein A1, X, A2, R1a, R1b, R1c, G, and z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及化合物I的取代吡啶化合物：（I）或其药学上可接受的盐，前药或溶剂，其中A1，X，A2，R1a，R1b，R1c，G和z如规范所述。本发明还涉及使用化合物I的方法来治疗对钠通道阻滞有反应的疾病。本发明的化合物特别适用于治疗疼痛。
• US9120752B2
  申请人：——

  公开号：US9120752B2

  公开（公告）日：2015-09-01
• US9765029B2
  申请人：——

  公开号：US9765029B2

  公开（公告）日：2017-09-19