(-)-trans-Pinocarveol-(4-nitro-benzoat) | 10446-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (-)-trans-Pinocarveol-(4-nitro-benzoat)
• 英文别名: 4-nitro-benzoic acid-((1S,3R)-pin-2(10)-en-3-yl ester)；4-Nitro-benzoesaeure-((1S,3R)-pin-2(10)-en-3-ylester)；(-)-O-(4-Nitro-benzoyl)-trans-pinocarveol
• CAS: 10446-49-8
• 化学式: C₁₇H₁₉NO₄
• 分子量: 301.342
• InChiKey: JLDNKZAERKYDJY-NWANDNLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.74
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  69.44
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  (-)-trans-pinocarveol 生成 (-)-trans-Pinocarveol-(4-nitro-benzoat)
  参考文献：
  名称：

  Calcium Intake and Bone Mass Development Among Israeli Adolescent Girls

  摘要：

  Objective: To determine the possible relationship between food and life style habits and bone health in adolescent Israeli females.Methods: 2,000 adolescent Israeli Jewish and Arab high-school girls (mean age 14.5) completed a semi-quantitative food frequency questionnaire and a personal history questionnaire. 27 food components were calculated fur each subject. Bone mineral content and density were determined for 112 subjects with calcium intake below 800 mg/day.Results: Average calcium intake was found to be 1,260 mg/day, but 20% of all girls had a calcium intake below 800 mg/day. All low-energy diets were very low in calcium, as mean calcium intake per 1,000 calories was 411 +/- 128 grams. A large percentage of diets with less than 800 mg calcium were also deficient in phosphorus (95.2%), magnesium (84.8%), iron (90.5%) and zinc (100%). Due to differences in food sources, Jewish girls had more phosphorus in their diet, but less magnesium and iron compared to Arab girls. Calcium and zinc deficiencies in Jewish and Arab diets were similar. A negative correlation was found between body mass index (BMI) and age at menarche for all girls in the study. Bone mineral density (BMD) measured for girls with calcium intake below 800 mg/day distributed normally around the average when compared to age matched controls despite their low calcium intake. There was a strong positive correlation between BMD and bone mineral content (BMC) at all sites and body weights.Conclusions: Low calcium intake, other nutritional deficiencies and delayed menarche due to low-energy diet in the growing period and in adolescence may prevent the formation of healthy bones. There is no evidence of lower bone mass among the low calcium intake group in the study population at this stage. It remains to be documented if the window of opportunity for optimal bone accretion for this group will be missed in the future, possibly lending to increased risk of osteoporosis.

  DOI：

  10.1080/07315724.2001.10719035