2-Fluoro-N,3-dimethylaniline | 502435-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Fluoro-N,3-dimethylaniline
• CAS: 502435-27-0
• 化学式: C₈H₁₀FN
• 分子量: 139.17
• InChiKey: DTUBDDHAZHNABD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES
  申请人：Yamamoto Keisuke

  公开号：US20100256134A1

  公开（公告）日：2010-10-07

  Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.

  提供了一种用于预防和/或治疗皮肤疾病的药剂，其中包含一种以式(I)表示的吡唑并嘧啶衍生物作为活性成分，其中每个符号如规范中所定义，或其药理学上可接受的盐等。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
  申请人：KYOWA HAKKO KIRIN CO., LTD.

  公开号：US20150299214A1

  公开（公告）日：2015-10-22

  The present invention provides a heterocyclic compound represented by the following formula (I), wherein X A represents CH and the like, R 1 represents cycloalkyl optionally having substituent(s) and the like, L represents a bond and the like, Y A represents —NH— and the like, R 2 represents a hydrogen atom and the like, R 3A represents the following formula (R 3A -1) (wherein, R 3 represents hydroxy and the like) and the like, and R 4A represents the following formula (R 4A -1) (wherein, R 4 and R 5 are the same or different and each represents a hydrogen atom and the like) and the like, or a pharmaceutically acceptable salt thereof, which is useful as a prophylactic and/or therapeutic agent for skin diseases and the like, and the like.

  本发明提供一种杂环化合物，其化学式表示为（I），其中XA代表CH等，R1代表环烷基，可选地具有取代基等，L代表键等，YA代表—NH—等，R2代表氢原子等，R3A代表下式（R3A-1）（其中，R3代表羟基等）等，R4A代表下式（R4A-1）（其中，R4和R5相同或不同，且每个代表氢原子等）等，或其药学上可接受的盐，其作为预防和/或治疗皮肤疾病等的药物具有用途。
• AGENT FOR PREVENTING AND/OR TREATING OCULAR INFLAMMATORY DISEASE
  申请人：KYOWA HAKKO KIRIN CO., LTD.

  公开号：US20160008362A1

  公开（公告）日：2016-01-14

  The invention provides a method for prophylaxis and/or treatment of an ocular inflammatory disease comprising administering an effective amount of a pyrazolopyrimidine compound represented by formula (I), wherein R 1 represents —NR 1a R 1b (wherein R 1a and R 1b are the same or different and each represents a hydrogen atom and the like), and the like, R 2 represents the formula (R 2 −1) [wherein k and m represent each an integer of 0-2, n represents an integer of 0-2, L represents a single bond and the like, R 5 represents a halogen and the like, R 6 represents aryl and the like, X represents —CR 8 (wherein R 8 represents a hydrogen atom and the like), and the like, R 7 represents a hydrogen atom, and the like, and the like, R 3 represents —SO 2 R 13 (wherein R 13 represents lower alkoxy and the like), and the like, and R 4 represents a hydrogen atom and the like, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种预防和/或治疗眼部炎症性疾病的方法，包括给予式(I)所表示的吡唑嘧啶化合物的有效量，其中R1表示—NR1aR1b（其中R1a和R1b相同或不同，每个表示氢原子等），R2表示式（R2-1）[其中k和m分别表示0-2的整数，n表示0-2的整数，L表示单键等，R5表示卤素等，R6表示芳基等，X表示—CR8（其中R8表示氢原子等），R7表示氢原子等，R3表示—SO2R13（其中R13表示低烷氧基等），R4表示氢原子等，或其药学上可接受的盐。
• ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
  申请人：Kangpu Biopharmaceuticals, Ltd.

  公开号：EP3214081A1

  公开（公告）日：2017-09-06

  Provided are an isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof. The isoindoline derivative and the pharmaceutical composition thereof can regulate the production or activity of immunological cytokines, thus effectively treating cancer and inflammatory disease.

  本文提供了一种异吲哚啉衍生物、中间体、制备方法、药物组合物及其用途。异吲哚啉衍生物及其药物组合物可以调节免疫细胞因子的产生或活性，从而有效治疗癌症和炎症性疾病。
• [EN] ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF<br/>[FR] DÉRIVÉ D'ISOINDOLINE, SON INTERMÉDIAIRE, SON PROCÉDÉ DE PRÉPARATION, SA COMPOSITION PHARMACEUTIQUE ET SON UTILISATION<br/>[ZH] 异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用
  申请人：KANGPU BIOPHARMACEUTICALS INC

  公开号：WO2016065980A1

  公开（公告）日：2016-05-06

  提供一种异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用。该异吲哚啉衍生物及其药物组合物能够调节免疫细胞因子的产生或活性，从而有效的治疗癌症和炎症性疾病。