tert-Butyl-[(1R,2S,4aS,4bS,7S,8aS,10aR)-7-methoxymethoxy-1-((R)-1-methoxymethoxy-5-methyl-hex-2-ynyl)-2,4b-dimethyl-tetradecahydro-phenanthren-2-ylmethoxy]-dimethyl-silane | 210641-90-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: tert-Butyl-[(1R,2S,4aS,4bS,7S,8aS,10aR)-7-methoxymethoxy-1-((R)-1-methoxymethoxy-5-methyl-hex-2-ynyl)-2,4b-dimethyl-tetradecahydro-phenanthren-2-ylmethoxy]-dimethyl-silane
• CAS: 210641-90-0
• 化学式: C₃₄H₆₂O₅Si
• 分子量: 578.949
• InChiKey: XZKLPBRABYQERV-AMJCWPPKSA-N

反应信息

• 作为反应物：
  描述：

  tert-Butyl-[(1R,2S,4aS,4bS,7S,8aS,10aR)-7-methoxymethoxy-1-((R)-1-methoxymethoxy-5-methyl-hex-2-ynyl)-2,4b-dimethyl-tetradecahydro-phenanthren-2-ylmethoxy]-dimethyl-silane 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以83%的产率得到[(1R,2S,4aS,4bS,7S,8aS,10aR)-7-Methoxymethoxy-1-((R)-1-methoxymethoxy-5-methyl-hex-2-ynyl)-2,4b-dimethyl-tetradecahydro-phenanthren-2-yl]-methanol
  参考文献：
  名称：

  Synthesis of the pentacyclic xestobergsterol skeleton

  摘要：

  An approach to the synthesis of the histamine release inhibitor xestobergsterol is described. The intramolecular Pauson-Khand reaction was used to generate the D and E rings of the steroid. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00345-7
• 作为产物：
  描述：

  叔丁基二甲硅基三氟甲磺酸酯 在 2,6-二甲基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 50.0h， 生成 tert-Butyl-[(1R,2S,4aS,4bS,7S,8aS,10aR)-7-methoxymethoxy-1-((R)-1-methoxymethoxy-5-methyl-hex-2-ynyl)-2,4b-dimethyl-tetradecahydro-phenanthren-2-ylmethoxy]-dimethyl-silane
  参考文献：
  名称：

  Synthesis of the pentacyclic xestobergsterol skeleton

  摘要：

  An approach to the synthesis of the histamine release inhibitor xestobergsterol is described. The intramolecular Pauson-Khand reaction was used to generate the D and E rings of the steroid. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00345-7