10,22-Dimethyl-10,22-diazapentacyclo[12.8.0.02,11.03,8.015,20]docosa-1(14),2(11),3,5,7,12,15,17,19-nonaene-9,21-dione | 1263375-96-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 10,22-Dimethyl-10,22-diazapentacyclo[12.8.0.02,11.03,8.015,20]docosa-1(14),2(11),3,5,7,12,15,17,19-nonaene-9,21-dione
• CAS: 1263375-96-7
• 化学式: C₂₂H₁₆N₂O₂
• 分子量: 340.381
• InChiKey: QKNDZEVXPFHRPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻碘苯甲酰氯 在 4-二甲氨基吡啶 、 四丁基溴化铵 、 potassium acetate 、 palladium diacetate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.2h， 生成 10,22-Dimethyl-10,22-diazapentacyclo[12.8.0.02,11.03,8.015,20]docosa-1(14),2(11),3,5,7,12,15,17,19-nonaene-9,21-dione
  参考文献：
  名称：

  Palladium-Mediated Bis-Arylation of Inactivated and Activated Arenes

  摘要：

  A simple synthetic protocol has been developed for the bis-arylation of unactivated and activated arenes by the implementation of a palladium-catalyzed intramolecular cyclization strategy. The activated arenes give either linearly fused or angularly fused bis-cyclized product depending upon the substitutent present on the nitrogen atom, whereas inactivated arenes give only linearly fused product. The reaction has been carried out in two steps under ligand-free conditions.

  DOI：

  10.1080/00397910903531870

文献信息

• Palladium-Mediated Bis-Arylation of Inactivated and Activated Arenes
  作者：Krishna C. Majumdar、Nirupam De、Santanu Chakravorty

  DOI：10.1080/00397910903531870

  日期：2010.12.21

  A simple synthetic protocol has been developed for the bis-arylation of unactivated and activated arenes by the implementation of a palladium-catalyzed intramolecular cyclization strategy. The activated arenes give either linearly fused or angularly fused bis-cyclized product depending upon the substitutent present on the nitrogen atom, whereas inactivated arenes give only linearly fused product. The reaction has been carried out in two steps under ligand-free conditions.