11,15-Diethyl-11,13,15-triazapentacyclo[12.8.0.03,12.04,9.017,22]docosa-1(14),2,4,6,8,12,17,19,21-nonaene-10,16-dione | 1263375-97-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 11,15-Diethyl-11,13,15-triazapentacyclo[12.8.0.03,12.04,9.017,22]docosa-1(14),2,4,6,8,12,17,19,21-nonaene-10,16-dione
• CAS: 1263375-97-8
• 化学式: C₂₃H₁₉N₃O₂
• 分子量: 369.423
• InChiKey: AWTWUFJJBKWAEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  53.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻碘苯甲酰氯 在 4-二甲氨基吡啶 、 四丁基溴化铵 、 potassium acetate 、 palladium diacetate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 生成 11,15-Diethyl-11,13,15-triazapentacyclo[12.8.0.03,12.04,9.017,22]docosa-1(14),2,4,6,8,12,17,19,21-nonaene-10,16-dione
  参考文献：
  名称：

  Palladium-Mediated Bis-Arylation of Inactivated and Activated Arenes

  摘要：

  A simple synthetic protocol has been developed for the bis-arylation of unactivated and activated arenes by the implementation of a palladium-catalyzed intramolecular cyclization strategy. The activated arenes give either linearly fused or angularly fused bis-cyclized product depending upon the substitutent present on the nitrogen atom, whereas inactivated arenes give only linearly fused product. The reaction has been carried out in two steps under ligand-free conditions.

  DOI：

  10.1080/00397910903531870

文献信息

• Palladium-Mediated Bis-Arylation of Inactivated and Activated Arenes
  作者：Krishna C. Majumdar、Nirupam De、Santanu Chakravorty

  DOI：10.1080/00397910903531870

  日期：2010.12.21

  A simple synthetic protocol has been developed for the bis-arylation of unactivated and activated arenes by the implementation of a palladium-catalyzed intramolecular cyclization strategy. The activated arenes give either linearly fused or angularly fused bis-cyclized product depending upon the substitutent present on the nitrogen atom, whereas inactivated arenes give only linearly fused product. The reaction has been carried out in two steps under ligand-free conditions.