N-(3-Pyridinylmethylene)-4-chlorobenzenesulfonamide | 137505-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-Pyridinylmethylene)-4-chlorobenzenesulfonamide
• 英文别名: 4-chloro-N-(pyridin-3-ylmethylidene)benzenesulfonamide
• CAS: 137505-14-7
• 化学式: C₁₂H₉ClN₂O₂S
• mdl: MFCD02344758
• 分子量: 280.735
• InChiKey: POBQREGGXMKCQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3-Pyridinylmethylene)-4-chlorobenzenesulfonamide 、 S-ethyl buta-2,3-dienethioate 在 C₁₉H₂₂NO₃PS 作用下， 以 苯 为溶剂， 反应 48.0h， 以42%的产率得到S-ethyl (2R)-1-(4-chlorophenyl)sulfonyl-2-pyridin-3-yl-2,5-dihydropyrrole-3-carbothioate
  参考文献：
  名称：

  [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CALCIUM ION HOMEOSTASIS
  [FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'HOMÉOSTASIE DES IONS CALCIUM

  摘要：

  本公开涉及能够调节钙离子稳态并治疗相关疾病的化合物。此外，本公开还涉及制备上述化合物的方法。

  公开号：

  WO2021163493A1
• 作为产物：
  描述：

  3-吡啶甲醛 、 4-氯苯磺酰胺 在 MP-TsOH 作用下， 以 甲苯 为溶剂， 生成 N-(3-Pyridinylmethylene)-4-chlorobenzenesulfonamide
  参考文献：
  名称：

  Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors

  摘要：

  Discovery of a series of pyrazolopiperidine sulfonamide based gamma-secretase inhibitors and its SAR evolution is described. Significant increases in APP potency on the pyrazolopiperidine scaffold over the original N-bicyclic sulfonamide scaffold were achieved and this potency increase translated in an improved in vivo efficacy. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.039

文献信息

• Novel gamma secretase inhibitors
  申请人：Pissarnitski A. Dmitri

  公开号：US20050085506A1

  公开（公告）日：2005-04-21

  This invention discloses novel gamma secretase inhibitors of the formula: wherein: R 1 is a substituted aryl or substituted heteroaryl group; R 2 is an R 1 group, alkyl, —XC(O)Y, alkylene-XC(O)Y, cycloalkylene-X—C(O)—Y, —CH—X—C(O)—NR 3 —Y or —CH—X—C(O)—Y, wherein X and Y are as defined herein; each R 3 and each R 3A are independently H, or alkyl; R 11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer's Disease using one or more compounds of the invention.

  本发明披露了一种新型的伽马分泌酶抑制剂，其化学式为：其中：R1是取代芳基或取代杂环芳基基团；R2是R1基团，烷基，—XC（O）Y，烷基- XC（O）Y，环烷基-X—C（O）—Y，—CH—X—C（O）—NR3—Y或—CH—X—C（O）—Y，其中X和Y的定义如下；每个R3和每个R3A都是独立的H或烷基；R11是芳基，杂环芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂环芳基烷基，杂环芳基环烷基，芳基杂环环烷基或烷氧基烷基。本发明还披露了使用本发明的一种或多种化合物治疗阿尔茨海默病的方法。
• Sulfonimines as bleach catalysts
  申请人：Lever Brothers Company, Division of Conopco, Inc.

  公开号：US05463115A1

  公开（公告）日：1995-10-31

  Novel bleach catalysts, a method for bleaching substrates using these catalysts and detergent compositions containing the catalysts are reported. The catalysts are sulfonimines. Substrates such as fabrics may be bleached in an aqueous solution containing the sulfonimine and a peroxygen compound.

  报道了一种新型漂白催化剂、使用这些催化剂漂白基质的方法以及含有这些催化剂的洗涤剂配方。这些催化剂是磺酰亚胺。基质，如织物，可以在含有磺酰亚胺和过氧化物化合物的水溶液中漂白。
• Activation of bleach precursors with sulfonimines
  申请人：Lever Brothers Company, Division of Conopco, Inc.

  公开号：US05047163A1

  公开（公告）日：1991-09-10

  A bleaching composition is described that includes a peroxygen compound such as sodium perborate, an oxygen transfer agent such as a sulfonimine, and a bleach precursor such as TAED. These sulfonimines at relatively low concentrations enhance the activity of the precursor. A method for bleaching substrates is also provided, especially a method for cleaning fabrics.

  本发明涉及一种漂白组合物，包括过氧化物化合物，例如过硼酸钠，氧传递剂，例如磺酰亚胺，以及漂白前体，例如TAED。这些磺酰亚胺在相对较低的浓度下增强了前体的活性。本发明还提供了一种漂白基质的方法，特别是一种清洁织物的方法。
• Gamma secretase inhibitors
  申请人：Schering Corporation

  公开号：US07256186B2

  公开（公告）日：2007-08-14

  This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 is an R1 group, alkyl, —XC(O)Y, alkylene-XC(O)Y, cycloalkylene-X—C(O)—Y, —CH—X—C(O)—NR3—Y or —CH—X—C(O)—Y, wherein X and Y are as defined herein; each R3 and each R3A are independently H, or alkyl; R11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer's Disease using one or more compounds of the invention.

  本发明披露了一种新型伽马分泌酶抑制剂，其化学式为：其中：R1是取代芳基或取代杂环芳基基团；R2是R1基团、烷基、—XC(O)Y、烷基- XC(O)Y、环烷基-X—C(O)—Y、—CH—X—C(O)—NR3—Y或—CH—X—C(O)—Y，其中X和Y的定义如本文所述；每个R3和每个R3A独立地是H或烷基；R11是芳基、杂环芳基、烷基、环烷基、芳基烷基、芳基环烷基、杂环芳基烷基、杂环芳基环烷基、芳基杂环环烷基或烷氧基烷基。本发明还披露了使用本发明中的一个或多个化合物治疗阿尔茨海默病的方法。