4-(tetrahydropyran-2-yl)-pyrrolidine | 64935-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 4-(tetrahydropyran-2-yl)-pyrrolidine
• 英文别名: 2-Pyrrolidino-tetrahydropyran；1-tetrahydropyran-2-yl-pyrrolidine；1-(Oxan-2-yl)pyrrolidine
• CAS: 64935-11-1
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: BJESJGOTMMGXJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 3,4-二氢-2H-吡喃 在 K2Pd(SCN)4 作用下， 反应 16.0h， 以52%的产率得到4-(tetrahydropyran-2-yl)-pyrrolidine
  参考文献：
  名称：

  Palladium-catalyzed addition of R 2 NH to double bonds. Synthesis of α-amino tetrahydrofuran and pyran rings

  摘要：

  Efficient addition of (RRNH)-R-1-N-2 to unsaturated heterocycles has been achieved using palladium catalysts. The methodology was applied to the synthesis of a number of alpha -amino, tetrahydrofurans and pyrans. Nature of amine, ring size and catalyst were found to affect the reaction. Mechanistic aspects of the reactions were explored by deuterium labelling experiments. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00446-x

文献信息

• IMIDAZO PYRAZINES
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2686319A1

  公开（公告）日：2014-01-22
• [EN] IMIDAZO PYRAZINES<br/>[FR] IMIDAZO PYRAZINES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012123470A1

  公开（公告）日：2012-09-20

  There are provided the compounds of formula I and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of AML.