3-Fluoro-5-(pyrrolidin-1-yl)aniline | 258864-26-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-Fluoro-5-(pyrrolidin-1-yl)aniline
• 英文别名: 3-fluoro-5-pyrrolidin-1-ylaniline
• CAS: 258864-26-5
• 化学式: C₁₀H₁₃FN₂
• mdl: MFCD12799890
• 分子量: 180.22
• InChiKey: SNPUUEFAXHZDGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Amidobenzamide derivatives which are useful as cytokine inhibitors
  申请人：Brown S. Dearg

  公开号：US20050038081A1

  公开（公告）日：2005-02-17

  The invention concerns amide derivatives of the Formula (I) wherein R 3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluoromethyl, cyano, (1-6C)alkyl, (1-6C)alkoxy, halogeno-(1-6C)alkyl, hydroxyl-(1-6C)alkyl, di-[(1-6C)akly]amino-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, (1-6C)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, amino(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, aryl-(1-6C)alkoxy, heteroaryl, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyl-(1-6C)alkyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and R 2 is a substituent such as hydroxy and halogeno; q is 0-4; and R 4 includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

  本发明涉及公式（I）的酰胺衍生物，其中R3是（1-6C）烷基或卤素基; Q是芳基或杂环芳基，其可选地带有1、2、3或4个取代基，例如羟基、卤素基、三氟甲基、氰基、（1-6C）烷基、（1-6C）烷氧基、卤代（1-6C）烷基、羟基（1-6C）烷基、二-[(1-6C)烷基]氨基（1-6C）烷基、羟基（2-6C）烷氧基、（1-6C）烷氧基（2-6C）烷氧基、二-[(1-6C)烷基]氨基（2-6C）烷氧基、氨基（2-6C）烷基氨基、N-(1-6C)烷基-(1-6C)烷基氨基-(2-6C)烷基氨基、芳基、芳基-(1-6C)烷氧基、杂环芳基、杂环芳基-(1-6C)烷氧基、杂环基、杂环基-(1-6C)烷基、杂环氧基和杂环基-(1-6C)烷氧基; p为0-2，R2是羟基和卤素基等取代基; q为0-4; R4包括可选的取代芳基、环烷基、杂环芳基和杂环基; 或其药学上可接受的盐或体内可水解的酯; 以及制备它们的方法、包含它们的制药组合物以及它们在治疗由细胞因子介导的疾病或医疗条件中的用途。
• AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP1102743A1

  公开（公告）日：2001-05-30
• US6821965B1
  申请人：——

  公开号：US6821965B1

  公开（公告）日：2004-11-23
• US7772432B2
  申请人：——

  公开号：US7772432B2

  公开（公告）日：2010-08-10
• [EN] AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS<br/>[FR] DERIVES D'AMIDES UTILES COMME INHIBITEURS DE CYTOKINE
  申请人：ZENECA LTD

  公开号：WO2000007980A1

  公开（公告）日：2000-02-17

  The invention concerns amide derivatives of the Formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluoromethyl, cyano, (1-6C)alkyl, (1-6C)alkoxy, halogeno-(1-6C)alkyl, hydroxy-(1-6C)alkyl, di-[(1-6C)aklyl]amino-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, (1-6C)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, amino-(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, aryl-(1-6C)alkoxy, heteroaryl, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyl-(1-6C)alkyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and R2 is a substituent such as hydroxy and halogeno; q is 0-4; and R4 includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatement of diseases or medical conditions mediated by cytokines.