((R)-2,5-dioxo-imidazolidin-4-yl)-methanesulfonic acid | 40856-82-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: ((R)-2,5-dioxo-imidazolidin-4-yl)-methanesulfonic acid
• 英文别名: ((R)-2,5-Dioxo-imidazolidin-4-yl)-methansulfonsaeure；[(4R)-2,5-dioxoimidazolidin-4-yl]methanesulfonic acid
• CAS: 40856-82-4
• 化学式: C₄H₆N₂O₅S
• 分子量: 194.168
• InChiKey: SXTLWEVCBALQMG-REOHCLBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 ((R)-2,5-dioxo-imidazolidin-4-yl)-methanesulfonic acid
  参考文献：
  名称：

  Distribution of 5-Carboxymethylhydantoinase

  摘要：

  THE enzyme 5-carboxymethylhydantoinase, which reversibly cyclized carbamylaspartate to 5-carboxymethylhydantoin, was demonstrated in Zymobacterium oroticum by Lieberman and Kornberg1. No enzymatic activity was found in rat liver or in two corynebacterium strains2. In recent studies on pyrimidine metabolism in man this enzyme was found to be absent in erythrocytes and normal or leukæmic leukocytes3,4. The absence of this enzyme in mammalian cells and its presence in bacteria suggested the possibility that chemotherapeutic agents might be developed as competitive inhibitors of 5-carboxy-methylhydahtoinase. Inhibition of the growth of Lactobacillus casei by thiohydantoin-5-acetic acid has been reported5. A survey of the distribution of the enzyme in micro-organisms was therefore undertaken.

  DOI：

  10.1038/1841314a0