N-[3-(2-diisopropylamino)ethoxy-4-methoxyphenyl]-4'-cyano-2'-methyl-1,1'-biphenyl-4-carboxamide | 219784-79-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-(2-diisopropylamino)ethoxy-4-methoxyphenyl]-4'-cyano-2'-methyl-1,1'-biphenyl-4-carboxamide
• 英文别名: 4-(4-cyano-2-methylphenyl)-N-[3-[2-[di(propan-2-yl)amino]ethoxy]-4-methoxyphenyl]benzamide
• CAS: 219784-79-9
• 化学式: C₃₀H₃₅N₃O₃
• 分子量: 485.626
• InChiKey: QDBAJOUPRAHKBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOUNDS FOR THE TREATMENT OF CCR5-MEDIATED DISEASES
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1001766B1

  公开（公告）日：2003-04-09
• US6515027B1
  申请人：——

  公开号：US6515027B1

  公开（公告）日：2003-02-04
• [EN] METHODS AND COMPOSITIONS FOR TREATING CYTOKINE STORM INFECTIONS, INCLUDING COVID-19, BY INHIBITING CCR5/CCL5 INTERACTION<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT D'INFECTIONS DE TYPE CHOC CYTOKINIQUE, NOTAMMENT LA COVD-19, PAR INHIBITION DE L'INTERACTION CCR5/CCL5
  申请人：INCELLDX INC

  公开号：WO2021222069A1

  公开（公告）日：2021-11-04

  Methods of treating a subject suffering from COVID-19 are provided. Aspects of the methods including administering to the subject an effective amount of an inhibitor of CCR5/CCL5 interaction, such as a CCR5 antagonist. Also provided are methods of assessing severity of a disease involving hypercytokinemia, such as COVID-19, by determining the level of CCL5/RANTES in a subject, as well as compositions for use in such methods.