2-chloro-N-(5-(2-chloro-5-(thiazol-2-yl)phenyl)pyridin-2-yl)-6-fluorobenzamide | 1113042-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-chloro-N-(5-(2-chloro-5-(thiazol-2-yl)phenyl)pyridin-2-yl)-6-fluorobenzamide
• 英文别名: 2-chloro-N-[5-[2-chloro-5-(1,3-thiazol-2-yl)phenyl]pyridin-2-yl]-6-fluorobenzamide
• CAS: 1113042-65-1
• 化学式: C₂₁H₁₂Cl₂FN₃OS
• 分子量: 444.316
• InChiKey: ACXBTXXLWDBYKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES<br/>[FR] COMPOSÉS PYRIDINE UTILISÉS POUR DES ÉTATS INFLAMMATOIRES ET DES TROUBLES IMMUNITAIRES
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2009017819A1

  公开（公告）日：2009-02-05

  The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

  这项发明涉及一类可用作免疫抑制剂、用于治疗和预防炎症性疾病、过敏性疾病和免疫性疾病的化合物。
• PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
  申请人：Chen Shoujun

  公开号：US20120064121A1

  公开（公告）日：2012-03-15

  The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

  这项发明涉及一类可用作免疫抑制剂以及用于治疗和预防炎症性疾病、过敏性疾病和免疫性疾病的化合物。
• METHOD OF CONSTRUCTING AND SCREENING LIBRARIES OF PEPTIDE STRUCTURES
  申请人：Phylogica Limited

  公开号：EP1987178B1

  公开（公告）日：2015-03-25
• PEPTIDE INHIBITORS OF CD40L SIGNALING AND USES THEREFOR
  申请人：Phylogica Limited

  公开号：EP2310405A1

  公开（公告）日：2011-04-20
• Methods of constructing and screening libraries of peptide structures
  申请人：Watt Michael Paul

  公开号：US20080081768A1

  公开（公告）日：2008-04-03

  The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.