One-Pot Sequential Synthesis of β-Hydroxy-1,4-disubstituted-1,2,3-triazoles from in-situ Generated β-Azido Alcohol by Click Chemistry
摘要:
beta-Hydroxy 1,2,3-triazoles from in situ generated 1,2-azidols were synthesized employing two sequential click reactions in very high yields with high regioselectivity using Cu(OAc)(2 center dot)H(2)O as a catalyst in water at ambient temperature.