{[2-Fluoro-3-(trifluoromethyl)phenyl]methyl}(methyl)amine | 958863-62-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {[2-Fluoro-3-(trifluoromethyl)phenyl]methyl}(methyl)amine
• 英文别名: 1-[2-fluoro-3-(trifluoromethyl)phenyl]-N-methylmethanamine
• CAS: 958863-62-2
• 化学式: C₉H₉F₄N
• 分子量: 207.17
• InChiKey: QAMQJZBGYWNMDX-UHFFFAOYSA-N

物化性质

• 沸点：
  184.3±35.0 °C(Predicted)
• 密度：
  1.227±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Bicyclic pyrimidine derivatives
  申请人：Arai Hitoshi

  公开号：US20070037834A1

  公开（公告）日：2007-02-15

  [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R 1 represents —NR 4 R 5 (wherein R 4 and R 5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R 2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(═O)—, —SO 2 —, —OC(═O)— or the like; and R 3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.

  提供上述公式（I）所代表的双环嘧啶衍生物，其中m和n可以相同或不同，每个表示1至3的整数，其中m+n小于等于4；R1表示—NR4R5（其中R4和R5可以相同或不同，每个表示氢原子，取代或未取代的低碳基，取代或未取代的芳基烷基或类似物）；R2表示上述公式（II），公式（IV）或类似物；A表示单键，—C（═O）—，—SO2—，—OC（═O）—或类似物；R3表示取代或未取代的低碳基，取代或未取代的环烷基，取代或未取代的芳基烷基或类似物。还提供了上述公式（I）所代表的四元铵盐或药学上可接受的盐或类似物。这些化合物具有抗炎活性或对TARC和/或MDC功能的调节活性，并且用于治疗和/或预防与T细胞相关的疾病，例如过敏性疾病，自身免疫性疾病或移植排斥。
• COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT
  申请人：Ardelyx, Inc.

  公开号：US20150164876A1

  公开（公告）日：2015-06-18

  Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, A, R 1 and R 2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本发明公开了一种作为磷酸盐转运抑制剂的化合物，更具体地，是肠道顶膜Na/磷酸盐共转运抑制剂。该化合物具有以下结构（I）：包括立体异构体、药学上可接受的盐和其前药，其中X、Y、A、R1和R2如本文所定义。本发明还公开了与制备和使用这种化合物相关的方法，以及包含这种化合物的药物组合物。
• US7524852B2
  申请人：——

  公开号：US7524852B2

  公开（公告）日：2009-04-28
• US9301951B2
  申请人：——

  公开号：US9301951B2

  公开（公告）日：2016-04-05
• [EN] INHIBITORS OF ION CHANNELS<br/>[FR] INHIBITEURS DE CANAUX IONIQUES
  申请人：ICAGEN INC

  公开号：WO2008118758A1

  公开（公告）日：2008-10-02

  [EN] Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
  [FR] L'invention concerne des composés, compositions et procédés utiles dans le traitement d'une maladie par inhibition du flux d'ions sodium dans des canaux sodiques sensibles au voltage. Plus particulièrement, l'invention propose des arylsulfonamides substitués, des compositions comprenant ces composés ainsi que des procédés d'utilisation de ces composés et compositions dans le traitement de troubles du système nerveux central ou périphérique, plus spécifiquement de douleurs et de douleurs chroniques, en bloquant les canaux sodiques associés au départ ou à la récurrence des affections indiquées. Les composés, compositions et procédés décrits dans la présente invention trouvent une utilisation spécifique dans le traitement de douleurs neuropathiques ou inflammatoires par l'inhibition du flux ionique dans un canal sodique sensible au voltage.