t-butyl 2-(2'-deoxy-2'-[4-benzoylphenyl]methylamino-6'-[N-(N-(N-(biotinyl)glycyl)glycyl)glycyla]-amino-6'-deoxy-β-D-galactopyranosyloxy)-3-hydroxyphenylpropanoate | 864070-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: t-butyl 2-(2'-deoxy-2'-[4-benzoylphenyl]methylamino-6'-[N-(N-(N-(biotinyl)glycyl)glycyl)glycyla]-amino-6'-deoxy-β-D-galactopyranosyloxy)-3-hydroxyphenylpropanoate
• CAS: 864070-89-3
• 化学式: C₄₉H₆₃N₇O₁₃S
• 分子量: 990.144
• InChiKey: HRAJSCIOVLXWQQ-JGXNTKNJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.69
• 重原子数：
  70.0
• 可旋转键数：
  23.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  292.08
• 氢给体数：
  10.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  t-butyl 2-(2'-deoxy-2'-[4-benzoylphenyl]methylamino-6'-[N-(N-(N-(biotinyl)glycyl)glycyl)glycyla]-amino-6'-deoxy-β-D-galactopyranosyloxy)-3-hydroxyphenylpropanoate 在 三氟乙酸 作用下， 反应 1.0h， 以51%的产率得到2-(2'-deoxy-2'-[4-benzoylphenyl]methylamino-6'-[N-(N-(N-(biotinyl)glycyl)glycyl)glycyla]-amino-6'-deoxy-β-D-galactopyranosyloxy)-3-hydroxyphenylpropanoic acid
  参考文献：
  名称：

  Detection of 210 kDa receptor protein for a leaf-movement factor by using novel photoaffinity probes

  摘要：

  Circadian rhythmic plant leaf-movement, called nyctinasty, is controlled by a time-course change in the internal concentration of the leaf-movement factor in the plant body. We revealed that specific binding proteins (210 and 180 kDa) for the leaf-movement factor, potassium lespedezate (1), are contained in the plasma membrane of the plant motor cell by using novel synthetic photoaffinity probes. These proteins are localized on the motor cell in the plant body, and would be potential receptors for the leaf-movement factor to control the leaf-movement. Our study is a rare successful result of the detection of membrane receptors by using a synthetic photoaffinity probe designed on a biologically active natural product. And these results also advance a guideline for probe design towards successful photoaffinity labeling. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.06.022
• 作为产物：
  描述：

  N-[N-[N-[叔丁氧羰基]甘氨酰]甘氨酰]甘氨酸 在 氢氧化钾 、 1-羟基苯并三唑 、 一水合肼 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 、 calcium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 93.83h， 生成 t-butyl 2-(2'-deoxy-2'-[4-benzoylphenyl]methylamino-6'-[N-(N-(N-(biotinyl)glycyl)glycyl)glycyla]-amino-6'-deoxy-β-D-galactopyranosyloxy)-3-hydroxyphenylpropanoate
  参考文献：
  名称：

  Detection of 210 kDa receptor protein for a leaf-movement factor by using novel photoaffinity probes

  摘要：

  Circadian rhythmic plant leaf-movement, called nyctinasty, is controlled by a time-course change in the internal concentration of the leaf-movement factor in the plant body. We revealed that specific binding proteins (210 and 180 kDa) for the leaf-movement factor, potassium lespedezate (1), are contained in the plasma membrane of the plant motor cell by using novel synthetic photoaffinity probes. These proteins are localized on the motor cell in the plant body, and would be potential receptors for the leaf-movement factor to control the leaf-movement. Our study is a rare successful result of the detection of membrane receptors by using a synthetic photoaffinity probe designed on a biologically active natural product. And these results also advance a guideline for probe design towards successful photoaffinity labeling. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.06.022