Bis[2-(sulphosuccinimidooxycarbonyloxy)ethyl]sulphone | 161011-72-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Bis[2-(sulphosuccinimidooxycarbonyloxy)ethyl]sulphone
• 英文别名: 1-[2-[2-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxycarbonyloxyethylsulfonyl]ethoxycarbonyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
• CAS: 161011-72-9
• 化学式: C₁₄H₁₆N₂O₁₈S₃
• 分子量: 596.5
• InChiKey: NOYCWFCBEPFQSX-UHFFFAOYSA-N

物化性质

• 密度：
  2.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  37
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  314
• 氢给体数：
  2
• 氢受体数：
  18

文献信息

• Molecular Imaging of Cancer Cells In Vivo
  申请人：Morse David L.

  公开号：US20140161725A1

  公开（公告）日：2014-06-12

  Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

  已经确定了可用于与靶向分子成像结合以在体内检测癌细胞的癌细胞细胞靶点。因此提供了用于检测癌细胞的非侵入性方法，例如转移性癌细胞。还提供了用于所述方法的组合物和试剂盒。
• Undercoating of solid phase surfaces and direct coating method
  申请人：Ciba Corning Diagnostics Corp.

  公开号：EP0643305A2

  公开（公告）日：1995-03-15

  An intermediate for use in forming a reagent for analysis of biological solutions is provided comprising a solid phase and an undercoating of inert material covalently or absorptively coated onto the solid phase. Additionally, a reagent is provided in which a binding partner of a reactant to be captured in a test assay is coupled to the undercoating. The solid phase may comprise superparamagnetic particles typically having highly irregular surface structures including small pores which consume binding partner in traditional loading procedures. In the inventive reagent, undercoating fills such small pores and covers the solid phase surface, reducing non-specific binding and allowing tailored loading of binding partner onto the solid phase.

  本发明提供了一种用于形成生物溶液分析试剂的中间体，包括固相和共价或吸收性涂布在固相上的惰性材料底涂层。此外，还提供了一种试剂，其中要在测试化验中捕获的反应物的结合伙伴与底涂层耦合。固相可由超顺磁性颗粒组成，这些颗粒通常具有高度不规则的表面结构，包括在传统装载程序中会消耗结合剂的小孔。在本发明的试剂中，底涂层填充了这些小孔并覆盖了固相表面，从而减少了非特异性结合，使结合剂能够按需装载到固相上。
• Modified nucleic acids and their use
  申请人：BioChip Technologies GmbH

  公开号：EP1111069A1

  公开（公告）日：2001-06-27

  The invention relates to a process for the modification of double-stranded nucleic acids with groups that allow a covalent binding of these nucleic acids to surfaces on supports or other substrates. In a further embodiment, the invention relates to a modified nucleic acid obtainable according to the method or process just mentioned. In a further embodiment, the present invention relates to a support carrying a covalently bonded modified nucleic acid, especially a DNA or RNA, where the nucleic acid is bonded via one or more modified nucleosides to the surface of said support In a further embodiment, the invention relates to a method of manufacturing a support carrying a covalently bonded modified nucleic acid, especially a DNA or RNA, where the nucleic acid is bonded via one or more modified nudeosides to the surface of said support. Furthermore, the invention relates to a matrix that may be gel-like and that is obtainable by cross-linking of a modified nucleid acid according to the invention with a cross-linker. The invention also relates to a method of manufacture of such a matrix. The invention also relates to a kit employing a support or matrix according to the invention, especially for detection or purification of nucleic acids, or nucleic acid binding (e.g. regulatory) proteins. In another embodiment, the present invention relates to a kit for introducing modified nucleosides into a nucleic acid and then covalently binding such a nucleic acid to a support.

  本发明涉及一种用基团修饰双链核酸的工艺，这些基团可使这些核酸与支持物或其他基质的表面共价结合。在另一个实施方案中，本发明涉及一种可根据上述方法或工艺获得的修饰核酸。在另一个实施方案中，本发明涉及一种携带共价键合修饰核酸（尤其是 DNA 或 RNA）的支持物，其中核酸通过一种或多种修饰核苷键合到所述支持物的表面。此外，本发明还涉及一种基质，该基质可以是凝胶状，可通过交联剂交联根据本发明修饰的核酸而获得。本发明还涉及一种制造这种基质的方法。本发明还涉及一种采用本发明的支持物或基质的试剂盒，特别是用于检测或纯化核酸或核酸结合蛋白（如调节蛋白）。在另一个实施方案中，本发明涉及一种试剂盒，用于将修饰的核苷引入核酸，然后将这种核酸与支持物共价结合。
• POLYPEPTIDE INDUCING APOPTOSIS
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1262548A1

  公开（公告）日：2002-12-04

  This invention relates to reconstructed polypeptides which have properties of inducing apoptosis of nucleated blood cells having Integrin Associated Protein (IAP) and causing no hemagglutination. The reconstructed polypeptides comprise two or more H chain V regions and two or more L chain V regions of a monoclonal antibody which induces apoptosis of nucleated blood cells having IAP. The reconstructed polypeptides are useful as a therapeutic agent for blood dyscrasia such as leukemia.

  本发明涉及一种重构多肽，它具有诱导具有整合素相关蛋白（IAP）的有核血细胞凋亡和不引起血凝现象的特性。重构多肽由两个或多个 H 链 V 区和两个或多个 L 链 V 区的单克隆抗体组成，该单克隆抗体可诱导具有 IAP 的有核血细胞凋亡。重构多肽可作为治疗血液病（如白血病）的药物。
• DEGRADED TPO AGONIST ANTIBODY
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1327680A1

  公开（公告）日：2003-07-16

  The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.

  本发明涉及一种修饰抗体，该抗体含有两个或两个以上单克隆抗体的 H 链 V 区和两个或两个以上 L 链 V 区，可通过交联 TPO 受体向细胞传递信号，从而发挥 TPO 激动剂的作用。经修饰的抗体可用作 TPO 信号转导激动剂，因此可用于预防和/或治疗各种疾病，如血小板减少相关的血液病、癌症或白血病化疗后的血栓性血小板减少症等。